CP-101537 is a Boc-protected bicyclic diamine with a free secondary ring nitrogen and a protected exocyclic amino group. This arrangement makes it useful for stepwise synthesis in which the two nitrogen atoms require different functionalisation.
Enamine lists Pfizer CP-101537 under PF-03339644. Its molecular formula is C10H18N2O2.
Application of CP-101537
The CP-101537 chemical structure allows chemists to modify the ring nitrogen while retaining protection at the 6-amino group. Subsequent acidic Boc removal exposes the second nitrogen for further reactions, provided the attached groups tolerate the deprotection conditions.
This sequence is relevant to preparing analogues containing the 6-amino-3-azabicyclo[3.1.0]hexane unit found in Trovafloxacin. Its rigid geometry also enables comparisons with more flexible amine scaffolds, although improved target selectivity must be demonstrated for each derivative.
In Vitro
A target-specific IC50, binding constant or cellular concentration-response relationship has not been established in the supplier descriptions reviewed. Listings that describe MMP inhibition or antibacterial activity do not provide sufficient assay detail to define potency or selectivity for this protected compound.
For solution preparation, the CP-101537 molecular weight is 198.26 g/mol. Solubility and solvent compatibility should be checked for the supplied batch rather than inferred from another supplier’s material.
In Vivo
The available product information does not establish an animal dose, exposure profile or efficacy endpoint for CAS 134575-17-0. Results obtained with Trovafloxacin or other finished molecules containing the bicyclic unit cannot be assigned to this intermediate. Such compounds differ in substitution, protection state and overall molecular properties.
Biochemical and Physiological Actions
The CP-101537 3-azabicyclo[3.1.0]hexane structure consists of a cyclopropane fused to a pyrrolidine ring. This constrains the relative positions of the ring nitrogen and the substituent at C6, providing a defined three-dimensional framework for analogue design.
The Boc group in the CP-101537 molecular structure masks the exocyclic amine; it does not protect the ring nitrogen. This distinction explains the compound’s synthetic reactivity but does not establish a biochemical mechanism or physiological effect.
Features and Benefits of CP-101537
The CP-101537 structure offers differentiated nitrogen reactivity and a preformed bicyclic framework, reducing the need to construct that ring system within each synthetic route. Confirm the relative stereochemistry against the structural record and batch documentation.
Use the CAS 134575-17-0 molecular weight for the Boc-protected form when calculating reagent quantities. Deprotected amines and their salts require their own formula weights; storage and handling should follow the supplied product documentation.
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