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EBCL-0037

Anticancer Compounds

Cancer, in its diverse forms, evades the body's regulatory mechanisms, resulting in tumor growth, metastasis, and the disruption of normal bodily functions. Understanding the interactions of small molecules with cancer cells can help to identify biomarkers for cancer diagnosis, prognosis, and treatment response. Various protein targets and biological pathways play a role in different types of cancer, offering a vast opportunity for the discovery and development of new cancer therapies.

Library of Anticancer compounds, compiled from the latest data within the KEGG database, offers a comprehensive collection of molecules that are intricately linked to specific targets within significant cancer-related pathways, providing valuable insights into their mechanisms and potential therapeutic uses. The database of targets encompasses various oncogenes, tumor suppressor genes, growth factors, and enzymes involved in cancer cell signaling, proliferation, and survival.

 This library includes approved drugs and investigational compounds, offering a valuable resource for research and drug development. It supports the identification of drug candidates and the repurposing of compounds for novel cancer targets.


Related terms: cancer, epoxide hydrolase, A2A, A3 receptor, fatty acid amide hydrolase, acetylcholinesterase, butyrylcholinesterase, carboxylesterase, Janus kinase

Library image

Preplated options

Dry powder/solution (DMSO)Dry powder
Number of compounds1826
Comment
Dry powder/solution (DMSO)DMSO
Number of compounds1627
Comment

Highlights

Molecule highlight
EBC-06774CAS: 1621375-48-1

3-Fluoro-4-methoxy-5-(2-morpholinothiazol-4-yl)phenol shows inhibitory activity against androgen receptor.

Molecule highlight
EBC-04207CAS: 117309-40-7

2-[N-(3-Chlorophenyl)benzenesulfonamido]acetic acid inhibits alcohol dehydrogenase (NADP+).

Molecule highlight
EBC-380073CAS: 1281683-44-0

dCeMM4 is a glue degrader that induces cyclin K Ubiquitination and degradation.

Molecule highlight
EBC-08359CAS: 75706-12-6

Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase.

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Disclaimer

All our products are for research purpose only. Any personal or non-scientific use is strictly prohibited.

Note

All the compounds with solubility below 10 mM are shipped as 2 mM solutions.

Product Features

  • Calculated structural diversity of the collection: 0.87.
  • 1826 molecules targeting various aspects of cancer biology.
  • Includes both approved drugs and investigational compounds, covering a wide range of therapeutic mechanism.
  • NMR and LCMS validated purity.
  • All compounds are available in stock for hit follow-up.
  • The library is continuously updated.

Product Details

  • Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
  • Container: 384-well microplates;
  • Storage: - 18 °C;
  • Shipping: Dry ice.

Utility

  • High throughput screening (HTS);
  • High content screening (HCS);
  • Cherry picking.