Dark Chemical Matter

The Dark Chemical Matter (DCM) Library is a collection of small molecules selected from published DCM data and further curated using PubChem BioAssay records. It brings together compounds with documented inactive screening results for exploratory screening, hit discovery, and chemical biology research.

Dark chemical matter describes compounds that remained inactive across extensive historical screening panels. This screening history does not exclude activity against other targets or under different experimental conditions. DCM therefore provides a starting point for discovering previously unrecognized biological activity through target-based and phenotypic screening.

Related terms: dark chemical matter, DCM, high-throughput screening, phenotypic screening, hit discovery, chemical biology.

Preplated options

Dry powder/solution (DMSO)Dry powder

Number of compounds669

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Disclaimer

All our products are for research purpose only. Any personal or non-scientific use is strictly prohibited.

Note

All the compounds with solubility below 10 mM are shipped as 2 mM solutions.

Product Features

Product features

Dark Chemical Matter Library is a set of 669 molecules for HTS/HCS programs.
Calculated structural diversity of the collection: 0.8.
Comprehensive documentation with structures, trivial names, synonyms and references.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.

Product Details

Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.

Utility

High throughput screening (HTS);
High content screening (HCS);
Cherry picking.