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Protein kinases are enzymes that catalyze the transfer of phosphate groups from ATP molecules to various substrates. The process is known as phosphorylation. Kinases regulate many cellar functions, so the overaction of protein kinases in cancer cells may cause fast tumor growth. Thus, kinase-inhibiting molecules might act as antitumor agents and can be used in cancer treatments.
Kinase Inhibitor Library designed by our specialists contains 2091 carefully selected small kinase inhibitors. It covers the wide scope of kinase targets and includes approved drugs, highly selective and broad-spectrum inhibitors, and the most recent discoveries.
Related terms: receptor tyrosine kinase, RTK, nRTK, CAMK, calcium/calmodulin-dependent protein kinase, mitogen-activated protein kinase, MAP, cyclin-dependent kinase, CDK, glycogen synthase kinase, GSK
Кinase action on substrate(Created by BioRender.com)
Fedratinib, approved 2019, cancer EBC-17140
Selective MAPK-14 inhibitor EBC-12783
H-7 is a broad spectrum kinase inhibitor EBC-101110
AAK1 and BMP2K inhibitor (2020) EBC-47126
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All our products are for research purpose only. Any personal or non-scientific use is strictly prohibited.
NoteAll the compounds with solubility below 10 mM are shipped as 2 mM solutions.
p38 subfamily
120
120
Number of compounds
120
"Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family"
110
110
Number of compounds
110
Others
108
108
Number of compounds
108
Rho kinase
104
104
Number of compounds
104
GSK subfamily
93
93
Number of compounds
93
Type I RTKs: ErbB (epidermal growth factor) receptor family
90
90
Number of compounds
90
Janus kinase (JakA) family
76
76
Number of compounds
76
Tec family
66
66
Number of compounds
66
Bromodomain kinase (BRDK) family
52
52
Number of compounds
52
Casein kinase 2 (CK2) family
49
49
Number of compounds
49
Abl family
46
46
Number of compounds
46
Aurora kinase (Aur) family
46
46
Number of compounds
46
Casein kinase 1 (CK1) family
40
40
Number of compounds
40
Leucine-rich repeat kinase (LRRK) family
38
38
Number of compounds
38
Src family
37
37
Number of compounds
37
"Phosphatidylinositol-4,5-bisphosphate 3-kinase family"
35
35
Number of compounds
35
ERK subfamily
33
33
Number of compounds
33
RAF family
33
33
Number of compounds
33
Interleukin-1 receptor-associated kinase (IRAK) family
32
32
Number of compounds
32
Type V RTKs: FGF (fibroblast growth factor) receptor family
32
32
Number of compounds
32
IKK family
32
32
Number of compounds
32
Receptor interacting protein kinase (RIPK) family
31
31
Number of compounds
31
Dyrk1 subfamily
31
31
Number of compounds
31
Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family
27
27
Number of compounds
27
CDK1 subfamily
27
27
Number of compounds
27
JNK subfamily
27
27
Number of compounds
27
Beta-adrenergic receptor kinases (βARKs)
27
27
Number of compounds
27
CDK4 subfamily
27
27
Number of compounds
27
PIM family
26
26
Number of compounds
26
LIMK subfamily
24
24
Number of compounds
24
Polo-like kinase (PLK) family
22
22
Number of compounds
22
MKN subfamily
20
20
Number of compounds
20
TAK1 subfamily
19
19
Number of compounds
19
Fak family
19
19
Number of compounds
19
IRE family
19
19
Number of compounds
19
STE7 family
18
18
Number of compounds
18
CLK family
17
17
Number of compounds
17
Pyruvate kinases (EC 2.7.1.40)
14
14
Number of compounds
14
Phosphatidylinositol kinases
14
14
Number of compounds
14
RSK subfamily
13
13
Number of compounds
13
CDK8 subfamily
13
13
Number of compounds
13
Tau tubulin kinase (TTBK) family
13
13
Number of compounds
13
Protein kinase A (PKA) family
12
12
Number of compounds
12
"Akt (Protein kinase B, PKB) family"
12
12
Number of compounds
12
Other PIKK family kinases
12
12
Number of compounds
12
MSN subfamily
12
12
Number of compounds
12
p70 subfamily
11
11
Number of compounds
11
S1: Chymotrypsin
11
11
Number of compounds
11
CDK9 subfamily
10
10
Number of compounds
10
Phosphatidylinositol 3-kinase family
10
10
Number of compounds
10
NAK family
9
9
Number of compounds
9
Transient Receptor Potential channels (TRP)
9
9
Number of compounds
9
Syk family
8
8
Number of compounds
8
"Inositol 1,4,5-trisphosphate 3-kinases"
8
8
Number of compounds
8
Death-associated kinase (DAPK) family
7
7
Number of compounds
7
Iota subfamily
7
7
Number of compounds
7
Delta subfamily
7
7
Number of compounds
7
Adenosine turnover
7
7
Number of compounds
7
1-phosphatidylinositol 4-kinase family
7
7
Number of compounds
7
Type X RTKs: HGF (hepatocyte growth factor) receptor family
6
6
Number of compounds
6
Csk family
6
6
Number of compounds
6
PDK1 family
6
6
Number of compounds
6
STE11 family
5
5
Number of compounds
5
GRK4 subfamily
5
5
Number of compounds
5
CAMK2 family
5
5
Number of compounds
5
Type XVII RTKs: ROS receptors
5
5
Number of compounds
5
MAPKAPK subfamily
5
5
Number of compounds
5
CAMK-unique family
5
5
Number of compounds
5
Protein kinase G (PKG) family
4
4
Number of compounds
4
Unc-51-like kinase (ULK) family
4
4
Number of compounds
4
PAKA subfamily
4
4
Number of compounds
4
Type II RTKs: Insulin receptor family
4
4
Number of compounds
4
CDK5 subfamily
4
4
Number of compounds
4
AMPK subfamily
4
4
Number of compounds
4
Phosphatidylinositol phosphate kinases
4
4
Number of compounds
4
Type XIV RTKs: RET
4
4
Number of compounds
4
FRAP subfamily
4
4
Number of compounds
4
Sphingosine kinase
4
4
Number of compounds
4
Type VII RTKs: Neurotrophin receptor/Trk family
4
4
Number of compounds
4
Cyclin-dependent kinase-like (CDKL) family
4
4
Number of compounds
4
Sugar phosphatases
4
4
Number of compounds
4
MAST family
4
4
Number of compounds
4
CAMK1 family
3
3
Number of compounds
3
HIPK subfamily
3
3
Number of compounds
3
CHK1 subfamily
3
3
Number of compounds
3
Pyruvate dehydrogenase kinase (PDHK) family
3
3
Number of compounds
3
KHS subfamily
3
3
Number of compounds
3
NIMA (never in mitosis gene a)- related kinase (NEK) family
3
3
Number of compounds
3
Type I receptor serine/threonine kinases
3
3
Number of compounds
3
PASK subfamily
3
3
Number of compounds
3
SGK family
3
3
Number of compounds
3
Eta subfamily
3
3
Number of compounds
3
Other PEK family kinases
3
3
Number of compounds
3
CDK7 subfamily
3
3
Number of compounds
3
SRPK family
2
2
Number of compounds
2
eEF2K subfamily
2
2
Number of compounds
2
Type XIII RTKs: Ephrin receptor family
2
2
Number of compounds
2
Type XII RTKs: TIE family of angiopoietin receptors
2
2
Number of compounds
2
PAKB subfamily
2
2
Number of compounds
2
SLK subfamily
2
2
Number of compounds
2
MSK subfamily
2
2
Number of compounds
2
TKL-unique family
2
2
Number of compounds
2
Protein kinase N (PKN) family
2
2
Number of compounds
2
MELK subfamily
2
2
Number of compounds
2
Meta subfamily
2
2
Number of compounds
2
ILK subfamily
2
2
Number of compounds
2
5-Hydroxytryptamine receptors
2
2
Number of compounds
2
CDC7 family
2
2
Number of compounds
2
STE-unique family
2
2
Number of compounds
2
HH498 subfamily
2
2
Number of compounds
2
MARK subfamily
2
2
Number of compounds
2
WEE family
1
1
Number of compounds
1
"Type XI RTKs: TAM (TYRO3-, AXL- and MER-TK) receptor family"
1
1
Number of compounds
1
Dopamine receptors
1
1
Number of compounds
1
MST subfamily
1
1
Number of compounds
1
CYP2 family: drug metabolising subset
1
1
Number of compounds
1
RIO1 subfamily
1
1
Number of compounds
1
"Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs)"
1
1
Number of compounds
1
Monoamine transporter subfamily
1
1
Number of compounds
1
Bub family
1
1
Number of compounds
1
Type II receptor serine/threonine kinases
1
1
Number of compounds
1
Haspin family
1
1
Number of compounds
1
TAO subfamily
1
1
Number of compounds
1
Ack family
1
1
Number of compounds
1
Organic zwitterions/cation transporters (OCTN)
1
1
Number of compounds
1
ABCG subfamily
1
1
Number of compounds
1
Chemokine receptors
1
1
Number of compounds
1
"CYP11, CYP17, CYP19, CYP20 and CYP21 families"
1
1
Number of compounds
1
QIK subfamily
1
1
Number of compounds
1
Wnk family
1
1
Number of compounds
1
DCAMKL family
1
1
Number of compounds
1
Inwardly rectifying potassium channels (KIR)
1
1
Number of compounds
1
Myosin Light Chain Kinase (MLCK) family
1
1
Number of compounds
1
Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family
1
1
Number of compounds
1
NuaK subfamily
1
1
Number of compounds
1
FRAY subfamily
1
1
Number of compounds
1
Neuropeptide Y receptors
1
1
Number of compounds
1
Erk7 subfamily
1
1
Number of compounds
1
TAIRE subfamily
1
1
Number of compounds
1
Leukotriene receptors
1
1
Number of compounds
1
Alpha subfamily
1
1
Number of compounds
1
EBCL-0020