JAK-STAT Signaling Ligands

The chemical signals outside of the cell to the cell nucleus are transferred by JAK-STAT signaling pathways. These pathways are involved in cell division and death, processes of the immune response, etc. Initially, the dimerization of the extracellular domains of receptor Janus kinase(JAK) brings together the intracellular domains of protein induced by ligand binding(cytokine, for example). The JAKs phosphorylate each other, resulting in the activation of the kinases. The activated JAKs can phosphorylate a regulator of gene expression called STAT(Signal Transducer and Activator of Transcription). Activated STAT moves to the nucleus to regulate gene expression. Any deviations during JAK-STAT signaling pathways may lead to cancer, serious skin diseases, or immune system disorders. Thus, investigation in this area is one of the valuable targets for drug discovery.

JAK-STAT Signaling Ligands Library contains 1129 small ligands, some representative molecules are given below: Pazopanib, VEGFR receptor inhibitor; LY294002, TPK inhibitor; PF06700841, JAK1 inhibitor; SH-4-54, STAT3 inhibitor.

Related terms: epidermal growth factor, Janus kinase, platelet derived growth factor, Pim-1 proto-oncogene, serine/threonine kinase, colony stimulating factor, interleukin