Back

EBCL-0018

Ion Channel Ligands

Ion channels are a large group of membrane proteins, also called the passive-transport systems, characterized by a very high ion-transport rate. Ion channels are represented in almost every type of living cell, as well as in cell organelles. They play a principal role in cell homeostasis and can be considered therapeutic targets for CNS disorders, pain control, inflammatory processes, cardiovascular diseases, and some pathogenic diseases. While many efficient ion channel-targeting drugs exist, these molecules remain a highly unexplored group of proteins.

Ion Channel Ligands Library is composed of 1869 small molecules. The library covers ligands suitable for application in many medicinal areas: cardiovascular regulation, neuroscience, pain suppression, and immune response regulation.


Related terms: CFTR, L-type calcium channel, Kv11.1, 5-HT3A, GABAA receptor, TRPA1, GluN2D, NMDA receptor, TRPV1, nicotinic acetylcholine receptor

Library image

Action of ion channel(Created by BioRender.com)

Preplated options

Dry powder/solution (DMSO)Dry powder
Number of compounds1869
Comment
Dry powder/solution (DMSO)DMSO
Number of compounds1403
Comment

Highlights

Molecule highlight
EBC-07659CAS: 19774-82-4

Amiodarone, antiarrythmic EBC-07659

Molecule highlight
EBC-14756CAS: 883093-10-5

Ro4938581, nootripic EBC-14756

Molecule highlight
EBC-11164CAS: 50700-72-6

Vecuronium bromide, anesthetic EBC-11164

Molecule highlight
EBC-11203CAS: 79794-75-5

Loratadine, antihistamine EBC-11203

Get an individual offer

We propose the complete list of Services powered by Enamine

Select size
Select format
Disclaimer

All our products are for research purpose only. Any personal or non-scientific use is strictly prohibited.

Note

All the compounds with solubility below 10 mM are shipped as 2 mM solutions.

Product Features

  • A set of 1869 ion channel binding molecules with sub-10 micromolar activity coefficient values for HTS/HCS programs.
  • The library is composed of ligands that target all major pharmaceutically relevant ion channel targets.
  • Ion Channel Ligands Library covers novel promising preclinical lead compounds, clinical candidates and approved drugs.
  • Calculated structural diversity of the collection: 0.88.
  • Comprehensive documentation with structures, trivial names, synonyms, activity coefficients values, types of action on target and references to original literature.
  • NMR and LCMS validated purity.
  • All the compounds are available in stock for hit follow-up.
  • The library is continuously updated.

Product Details

  • Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
  • Container: 384-well microplates;
  • Storage: - 18 °C;
  • Shipping: Dry ice.

Utility

  • High throughput screening (HTS);
  • High content screening (HCS);
  • Cherry picking.

Library Composition

Name
Occurrence in the library, times

CFTR

36

36

Number of compounds

36

L-type calcium channel

33

33

Number of compounds

33

Kv11.1

31

31

Number of compounds

31

5-HT3A

28

28

Number of compounds

28

GABAA receptor α1 subunit

27

27

Number of compounds

27

Show all
Enamine store logo
Enamine store logo

© 2026 Copyright Enamine