Photoaffinity Labeling (PAL)

Pfizer compound category

Photoaffinity labeling (PAL) is a successful and widespread strategy for the identification of interactions between small molecules and biological targets, primarily proteins, as well as protein-protein interactions (PPIs). Diazirines, benzophenones, and aryl azides are traditional and well-described photolabile classes used in PAL. Upon photoirradiation, these moieties produce highly reactive species that quickly react with adjacent protein parts, resulting in covalent binding, which can be further identified. At Enamine, we offer the largest and the most diverse source of Photoaffinity Compounds.