Growth Factors and Cytokines Ligands

Cytokines are signal molecules that bind to the receptor proteins on the surface of immune system cells, provoking an immunological response. They include chemokines, interferons, interleukins, lymphokines, and tumor necrosis factors. Growth factors are important molecules for the regulation of a variety of cellular processes. These compounds stimulate cell proliferation, regeneration, and cell differentiation. Together cytokines and growth factors are weighty parts of the immune system's responses to infection, inflammation, trauma, sepsis, cancer and reproduction, becoming prominent pharmaceutical targets.

Growth Factors and Cytokines Ligands Library contains 985 small ligands, some representative molecules are given below: Ceritinib, ALK tyrosine kinase receptor inhibitor; Lucitanib, VEGFR and FGFR inhibitor; MSX-127, CXCR4 antagonist; Eltrombopag, Thrombopoietin receptor agonist.

Related terms:  epidermal growth factor, fms related receptor tyrosine kinase, kinase insert domain receptor, fibroblast growth factor, platelet derived growth factor