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EBCL-0012

Apoptosis Related Ligands

Apoptosis is one of the programmed cell death (PDC) mechanisms in multicellular organisms. Biochemical cascade leads to morphological cell changes (cell shrinking, nuclear fragmentation, etc.) and death. This process is critical for maintaining the health of the organism by eliminating old or unhealthy cells. Apoptosis is controlled by Fas receptor and caspases (pro-apoptotic signaling) and Bcl-2/IAP (anti-apoptotic factors). The disbalance in the mechanism of apoptosis leads to atrophy in case of overstimulation, or cancer and related diseases in case of its suppression(the cells become “immortal”). It makes both processes of apoptosis (inhibition and stimulation) an important target for modern pharmacy and drug development.

Library of Apoptosis Related Ligands contains 342 small ligands, some representative molecules are given below: SP141, MDM2 inhibitor; ML-311, Mcl-1 inhibitor; Sepantronium bromide, a baculoviral IAP repeat containing 5 inhibitor.

Related terms: MDM2 proto-oncogene, caspase, calpain 2, Bcl-2-like 1

Library image

Apoptosis signaling pathways (Created by BioRender.com)

Preplated options

Dry powder/solution (DMSO)Dry powder
Number of compounds342
Comment
Dry powder/solution (DMSO)DMSO
Number of compounds341
Comment

Highlights

Molecule highlight
EBC-07836CAS: 1253491-42-7
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SP141, Mdm2 inhibitor EBC-07836

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EBC-07310CAS: 315698-17-0
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ML-311, Mcl-1 inhibitor EBC-07310

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EBC-11385CAS: 781661-94-7
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Sepantronium bromide, baculoviral IAP repeat containing 5 inhibitor EBC-11385

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Disclaimer

All our products are for research purpose only. Any personal or non-scientific use is strictly prohibited.

Note

All the compounds with solubility below 10 mM are shipped as 2 mM solutions.

Product Features

  • A set of 342 apoptosis related molecules with sub-10 micromolar activity coefficient values for HTS/HCS programs.
  • The library is composed of ligands that target all major pharmaceutically relevant apoptosis related targets.
  • Apoptosis Related Ligands Library covers novel promising preclinical lead compounds, clinical candidates and approved drugs.
  • Calculated structural diversity of the collection: 0.86.
  • Comprehensive documentation with structures, trivial names, synonyms, activity coefficient values, types of action on target and references to original literature.
  • NMR and LCMS validated purity.
  • All the compounds are available in stock for hit follow-up.
  • The library is continuously updated.

Product Details

  • Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
  • Container: 384-well microplates;
  • Storage: - 18 °C;
  • Shipping: Dry ice.

Utility

  • High throughput screening (HTS);
  • High content screening (HCS);
  • Cherry picking.

Library Composition

Name
Occurrence in the library, times

MDM2 proto-oncogene

12

12

Number of compounds

12

Caspase 3

6

6

Number of compounds

6

calpain 2

6

6

Number of compounds

6

Caspase 8

2

2

Number of compounds

2

Caspase 1

1

1

Number of compounds

1

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