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EBCL-0022
Nuclear hormone receptors (NHRs) are representatives of a large class of proteins within cells. They act as receptors for a wide range of molecules, such as vitamin A-derivative retinoids, steroid and thyroid hormones, and others. Activated by binding of the signal molecule, the ligand–NHR complex changes its conformation and modifies the expression of certain genes by binding to control elements in the DNA. Thus, NHRs play a major role in embryonic development and adult homeostasis. Over 10% of FDA-approved drugs target NHRs as perspective objects in the control of various diseases.
Nuclear Hormone Receptor Ligands Library is composed of 758 small ligands. The collection includes ligands that display all major types of action on NHR targets: agonistic, antagonistic, and inverse agonistic.
Related terms: pregnane X receptor, peroxisome proliferator-activated receptor, estrogen, androgen, farnesoid X receptor, vitamin D
Mechanism of action for class I NHRs(Created by BioRender.com)
Dienogest, progesterone receptor agonist EBC-07864
Darolutamide, androgen receptor antagonist EBC-17092
GSK805, ROR-gamma receptor inverse antagonist EBC-07875
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NoteAll the compounds with solubility below 10 mM are shipped as 2 mM solutions.
Pregnane X receptor
6
6
Number of compounds
6
Peroxisome proliferator-activated receptor-γ
6
6
Number of compounds
6
Estrogen receptor
3
3
Number of compounds
3
Peroxisome proliferator-activated receptor-α
3
3
Number of compounds
3
Androgen receptor
2
2
Number of compounds
2
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