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EBCL-0002

Bioactive Compounds II

Bioactive Library II is a collection of 5507 compounds with annotated biological activity. This collection is based on Bioactive Library I and contains compounds with sub-one micromolar activity coefficient values only.

Fully annotated: all compounds are provided with literature references and detailed and up to date biological activity data.
Custom Synthesis and Compound Sourcing: we can supply almost any compound either via in-house synthesis or using our supplier network.

Related terms: GPCR, carbonic anhydrase, ligand-gated ion channel, receptor tyrosine kinase, RTK, nRTK, cytochrome P450, voltage-gated ion channel, oxidoreductase, catecholamine turnover

Preplated options

Dry powder/solution (DMSO)Dry powder

Number of compounds5507

Comment

Dry powder/solution (DMSO)DMSO

Number of compounds4075

Comment

Highlights

EBC-11262CAS: 140462-76-6

Olopatadine is a selective histamine H1 antagonist and mast cell stabilizer that works by attenuating inflammatory and allergic reactions.

EBC-08734CAS: 303101-05-5

DHP-053 is a blocker of voltage-dependent L-type calcium channel.

EBC-00624CAS: 301305-73-7

TCS 359 is an inhibitor of receptor-type tyrosine-protein kinase FLT3.

EBC-13476CAS: 836620-48-5

AS1842856 is a specific Foxo1 inhibitor, it potently suppresses autophagy.

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Disclaimer

All our products are for research purpose only. Any personal or non-scientific use is strictly prohibited.

Note

All the compounds with solubility below 10 mM are shipped as 2 mM solutions.

Product Features

Enamine Bioactive Library II is a set of 5507 bioactive molecules for HTS/HCS programs.
The Bioactive Library II covers novel promising preclinical lead compounds,
clinical candidates and approved drugs.
Comprehensive documentation with structures, trivial names, synonyms, activity coefficient values, types of action on target and references to original literature.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.

Product Details

Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.

Utility

High throughput screening (HTS);
High content screening (HCS);
Cherry picking.

Library Composition

Name

Occurrence in the library, times

G protein-coupled receptors

963

Number of compounds

963

Carbonic anhydrases

522

Number of compounds

522

Ligand-gated ion channels

226

Number of compounds

226

Receptor tyrosine kinases (RTKs)

179

Number of compounds

179

Cytochrome P450

124

Number of compounds

124

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