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EBCL-0033

Psychoactive Drugs

The Library of Psychoactive Drugs is a curated collection of compounds known for their ability to have a significant impact on human brain function. These substances affect a person's perception, mood, consciousness, or behavior. The library encompasses a range of psychoactive agents, including sedatives, hypnotics, antipsychotics, and antidepressants. This data can serve as a valuable resource in research on the neurological and behavioral effects of psychoactive compounds.

The Library of Psychoactive Drugs contains 145 molecules. The mechanisms of action and their effects on the CNS are known for all presented compounds.

Related terms: Catechol-O-methyltransferase, GPСR, 5-HT2A receptor, antipsychotics, neurotrophic receptor tyrosine kinase, GABA, antidepressants, butyrylcholinesterase, TRPM6.

Library image

Preplated options

Dry powder/solution (DMSO)Dry powder
Number of compounds145
Comment
Dry powder/solution (DMSO)DMSO
Number of compounds135
Comment

Highlights

Molecule highlight
EBC-13572CAS: 106266-06-2

Risperidone is a second-generation antipsychotic medication.

Molecule highlight
EBC-03921CAS: 109889-09-0

Granisetron is a serotonin 5-HT3 receptor antagonist.

Molecule highlight
EBC-06994CAS: 14028-44-5

Amoxapine is a tetracyclic antidepressant.

Molecule highlight
EBC-26710CAS: 53583-79-2

Sultopride is an atypical antipsychotic used for the treatment of schizophrenia.

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Disclaimer

All our products are for research purpose only. Any personal or non-scientific use is strictly prohibited.

Note

All the compounds with solubility below 10 mM are shipped as 2 mM solutions.

Product Features

  • Psychoactive Drugs Library is a set of 132 molecules with sub-10 micromolar activity coefficient values for HTS/HCS programs.
  • The library comprises of psychoactive drugs, each with distinct mechanisms of action and effects on the CNS.
  • Calculated structural diversity of the collection: 0.86.
  • Comprehensive documentation with structures, trivial names, activity coefficient values, types of action on target and references to original literature.
  • NMR and LCMS validated purity.
  • All the compounds are available in stock for hit follow-up.
  • The library is continuously updated.

Product Details

  • Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
  • Container: 384-well microplates;
  • Storage: - 18 °C;
  • Shipping: Dry ice.

Utility

  • High throughput screening (HTS);
  • High content screening (HCS);
  • Cherry picking.

Library Composition

Name
Occurrence in the library, times

G protein-coupled receptors

48

48

Number of compounds

48

SLC6 neurotransmitter transporter family

9

9

Number of compounds

9

Catecholamine turnover

9

9

Number of compounds

9

Potassium channels

8

8

Number of compounds

8

Ligand-gated ion channels

8

8

Number of compounds

8

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