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EBCL-0001

Bioactive Compounds I

Bioactive Library I: we have synthesized and collected 11253 compounds with known biological activity, including over 1100 FDA-approved drugs, tool compounds, metabolites, prodrugs, and drug candidates.

Fully annotated: all compounds are provided with literature references and detailed and up to date biological activity data.
Custom Synthesis and Compound Sourcing: we can supply almost any compound either via in-house synthesis or using our supplier network.

Related terms: GPCR, carbonic anhydrase, ligand-gated ion channel, receptor tyrosine kinase, RTK, nRTK, cytochrome P450, voltage-gated ion channel, oxidoreductase, catecholamine turnover

Preplated options

Dry powder/solution (DMSO)Dry powder

Number of compounds11253

Comment

Dry powder/solution (DMSO)DMSO solution

Number of compounds6647

Comment

Highlights

EBC-09069CAS: 1628210-26-3

KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor, IC50 = 14nM.

EBC-07684CAS: 872628-31-4

Compound shows binding affinity to adenosine receptor a2a, Ki = 1.21 µM.

EBC-03833CAS: 91374-20-8

Ropinirole is a non-ergoline dopamine agonist. It is used for the treatment of the signs and symptoms of Parkinson's disease

EBC-11393CAS: 842133-18-0

Canagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor used to manage hyperglycemia in type 2 diabetes mellitus

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Disclaimer

All our products are for research purpose only. Any personal or non-scientific use is strictly prohibited.

Note

All the compounds with solubility below 10 mM are shipped as 2 mM solutions.

Product Features

Enamine Bioactive Library I is a set of 11253 bioactive molecules for HTS/HCS programs.
The Bioactive Library I covers novel promising preclinical lead compounds, clinical candidates and approved drugs.
Comprehensive documentation with structures, trivial names, synonyms, activity coefficient values, types of action on target and references to original literature.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.

Product Details

Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.

Utility

High throughput screening (HTS);
High content screening (HCS);
Cherry picking.

Library Composition

Name

Occurrence in the library, times

G protein-coupled receptors

1230

Number of compounds

1230

Carbonic anhydrases

668

Number of compounds

668

Ligand-gated ion channels

299

Number of compounds

299

Receptor tyrosine kinases (RTKs)

248

Number of compounds

248

Cytochrome P450

175

Number of compounds

175

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