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Bioactive Library I: we have synthesized and collected 11254 compounds with known biological activity, including over 1100 FDA-approved drugs, tool compounds, metabolites, prodrugs, and drug candidates.
Related terms: GPCR, carbonic anhydrase, ligand-gated ion channel, receptor tyrosine kinase, RTK, nRTK, cytochrome P450, voltage-gated ion channel, oxidoreductase, catecholamine turnover
KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor, IC50 = 14nM.
Compound shows binding affinity to adenosine receptor a2a, Ki = 1.21 µM.
Ropinirole is a non-ergoline dopamine agonist. It is used for the treatment of the signs and symptoms of Parkinson's disease
Canagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor used to manage hyperglycemia in type 2 diabetes mellitus
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NoteAll the compounds with solubility below 10 mM are shipped as 2 mM solutions.
G protein-coupled receptors
1230
1230
Number of compounds
1230
Carbonic anhydrases
668
668
Number of compounds
668
Ligand-gated ion channels
299
299
Number of compounds
299
Receptor tyrosine kinases (RTKs)
248
248
Number of compounds
248
Cytochrome P450
175
175
Number of compounds
175
Voltage-gated ion channels
160
160
Number of compounds
160
1.-.-.- Oxidoreductases
143
143
Number of compounds
143
Non-receptor tyrosine kinases (nRTKs)
138
138
Number of compounds
138
Catecholamine turnover
134
134
Number of compounds
134
Eicosanoid turnover
131
131
Number of compounds
131
Steroid hormone receptors
121
121
Number of compounds
121
Potassium channels
118
118
Number of compounds
118
Acetylcholine turnover
112
112
Number of compounds
112
Chromatin modifying enzymes
104
104
Number of compounds
104
Hydrolases
89
89
Number of compounds
89
SLC6 neurotransmitter transporter family
84
84
Number of compounds
84
Nuclear hormone receptors
81
81
Number of compounds
81
ATP-binding cassette transporter family
64
64
Number of compounds
64
MA: Metallo (M) Peptidases
63
63
Number of compounds
63
Endocannabinoid turnover
62
62
Number of compounds
62
SLC superfamily of solute carriers
61
61
Number of compounds
61
Poly ADP-ribose polymerases
59
59
Number of compounds
59
L-Arginine turnover
55
55
Number of compounds
55
Orphan and other 7TM receptors
53
53
Number of compounds
53
SLC22 family of organic cation and anion transporters
52
52
Number of compounds
52
Mitogen-activated protein kinases (MAP kinases)
45
45
Number of compounds
45
Sigma receptors
44
44
Number of compounds
44
PA: Serine (S) Peptidases
43
43
Number of compounds
43
MG: Metallo (M) Peptidases
42
42
Number of compounds
42
Chloride channels
38
38
Number of compounds
38
CA: Cysteine (C) Peptidases
37
37
Number of compounds
37
CAMK: Calcium/calmodulin-dependent protein kinases
35
35
Number of compounds
35
Cyclic nucleotide turnover/signalling
34
34
Number of compounds
34
Glycogen synthase kinase (GSK) family
32
32
Number of compounds
32
Cyclin-dependent kinase (CDK) family
31
31
Number of compounds
31
CAMK-like (CAMKL) family
26
26
Number of compounds
26
CMGC: Containing CDK, MAPK, GSK3, CLK families
25
25
Number of compounds
25
Aryl hydrocarbon receptor complex
24
24
Number of compounds
24
AGC: Containing PKA, PKG, PKC families
23
23
Number of compounds
23
Catalytic receptors
22
22
Number of compounds
22
SC: Serine (S) Peptidases
19
19
Number of compounds
19
Lanosterol biosynthesis pathway
19
19
Number of compounds
19
Tubulins
18
18
Number of compounds
18
1.13.11.- Dioxygenases
18
18
Number of compounds
18
IKK family
18
18
Number of compounds
18
CK1: Casein kinase 1
17
17
Number of compounds
17
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family
17
17
Number of compounds
17
CD: Cysteine (C) Peptidases
17
17
Number of compounds
17
STE20 family
16
16
Number of compounds
16
Pattern recognition receptors
15
15
Number of compounds
15
Glycerophospholipid turnover
15
15
Number of compounds
15
E3 ubiquitin ligase components
14
14
Number of compounds
14
STE: Homologs of yeast Sterile 7, Sterile 11, Sterile 20 kinases
14
14
Number of compounds
14
Protein kinase C (PKC) family
14
14
Number of compounds
14
RAF family
13
13
Number of compounds
13
Casein kinase 2 (CK2) family
12
12
Number of compounds
12
Heat shock proteins
11
11
Number of compounds
11
Bromodomain-containing proteins
11
11
Number of compounds
11
Receptor serine/threonine kinase (RSTK) family
11
11
Number of compounds
11
RSK family
10
10
Number of compounds
10
DMPK family
10
10
Number of compounds
10
MH: Metallo (M) Peptidases
10
10
Number of compounds
10
Adenosine turnover
9
9
Number of compounds
9
Transcription factors
9
9
Number of compounds
9
Viral protein targets
9
9
Number of compounds
9
Interleukin-1 receptor-associated kinase (IRAK) family
9
9
Number of compounds
9
NADPH oxidases
9
9
Number of compounds
9
SLC28 and SLC29 families of nucleoside transporters
8
8
Number of compounds
8
Aurora kinase (Aur) family
8
8
Number of compounds
8
AA: Aspartic (A) Peptidases
8
8
Number of compounds
8
G protein-coupled receptor kinases (GRKs)
8
8
Number of compounds
8
Alpha kinase family
8
8
Number of compounds
8
Ceramide turnover
7
7
Number of compounds
7
Phosphatidyl inositol 3' kinase-related kinases (PIKK) family
7
7
Number of compounds
7
Leucine-rich repeat kinase (LRRK) family
7
7
Number of compounds
7
Carrier proteins
6
6
Number of compounds
6
IRE family
6
6
Number of compounds
6
SLC5 family of sodium-dependent glucose transporters
6
6
Number of compounds
6
LIM domain kinase (LISK) family
6
6
Number of compounds
6
DNA topoisomerases
6
6
Number of compounds
6
SLC2 family of hexose and sugar alcohol transporters
6
6
Number of compounds
6
PB: Threonine (T) Peptidases
6
6
Number of compounds
6
GABA turnover
5
5
Number of compounds
5
1.14.13.9 Kynurenine 3-monooxygenase
5
5
Number of compounds
5
NAK family
5
5
Number of compounds
5
3.2.1.- Glycosidases
4
4
Number of compounds
4
MC: Metallo (M) Peptidases
4
4
Number of compounds
4
Mixed Lineage Kinase (MLK) family
4
4
Number of compounds
4
Bromodomain kinase (BRDK) family
4
4
Number of compounds
4
Amino acid hydroxylases
4
4
Number of compounds
4
Numb-associated kinase (NAK) family
4
4
Number of compounds
4
F-type and V-type ATPases
4
4
Number of compounds
4
5.2.-.- Cis-trans-isomerases
4
4
Number of compounds
4
MAPK-Activated Protein Kinase (MAPKAPK) family
4
4
Number of compounds
4
SLC1 family of amino acid transporters
4
4
Number of compounds
4
CD molecules
4
4
Number of compounds
4
WEE family
3
3
Number of compounds
3
1.4.3.13 Lysyl oxidases
3
3
Number of compounds
3
Fatty acid-binding proteins
3
3
Number of compounds
3
Polo-like kinase (PLK) family
3
3
Number of compounds
3
Inositol phosphate turnover
3
3
Number of compounds
3
2.1.1.- Methyltransferases
3
3
Number of compounds
3
Nucleotide turnover
3
3
Number of compounds
3
Immunoglobulin like domain containing proteins
2
2
Number of compounds
2
Lipid modifying kinases
2
2
Number of compounds
2
TKL-unique family
2
2
Number of compounds
2
Receptor interacting protein kinase (RIPK) family
2
2
Number of compounds
2
P-type ATPases
2
2
Number of compounds
2
Thyroid hormone turnover
2
2
Number of compounds
2
Cytokine receptor family
2
2
Number of compounds
2
Other ion channels
2
2
Number of compounds
2
Adiponectin receptors
2
2
Number of compounds
2
Haem oxygenase
2
2
Number of compounds
2
2.6.1.42 Branched-chain-amino-acid transaminase
2
2
Number of compounds
2
NIMA (never in mitosis gene a)- related kinase (NEK) family
2
2
Number of compounds
2
RIO family
2
2
Number of compounds
2
G-alpha family G(q) subfamily
1
1
Number of compounds
1
P2C P-type ATPases
1
1
Number of compounds
1
TTK family
1
1
Number of compounds
1
CAMKK family
1
1
Number of compounds
1
Carboxylases and decarboxylases
1
1
Number of compounds
1
Atypical
1
1
Number of compounds
1
Haspin family
1
1
Number of compounds
1
Phosphatases
1
1
Number of compounds
1
2.3.1.- Acyltransferases
1
1
Number of compounds
1
Mitochondrial-associated proteins
1
1
Number of compounds
1
Kelch-like proteins
1
1
Number of compounds
1
SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)
1
1
Number of compounds
1
3.4.21.46 Complement factor D
1
1
Number of compounds
1
SB: Serine (S) Peptidases
1
1
Number of compounds
1
MP: Metallo (M) Peptidases
1
1
Number of compounds
1
SLC17 phosphate and organic anion transporter family
1
1
Number of compounds
1
Sphingosine 1-phosphate turnover
1
1
Number of compounds
1
Hydrogen sulphide synthesis
1
1
Number of compounds
1
2.4.2.1 Purine-nucleoside phosphorylase
1
1
Number of compounds
1
EBCL-0001