GPCR-binding Ligands

G-protein coupled receptors (GPCRs) are the largest family of cell surface receptors. They are responsible for transmitting information initiated by various signals (such as photons, hormones, neurotransmitters, etc) into the cell. As GPCRs regulate a vast variety of signaling pathways in organisms, they are connected to many metabolic, neurological, inflammatory, cardiovascular and immunological disorders. Due to this fact, GPCRs are very important pharmaceutical targets with a highly promising future.

GPCR-binding Ligands Library contains 3005 small ligands, including molecules with inhibitory action against GPCR targets, agonists, and allosteric modulators.

Related terms: 5-hydroxytryptamine receptor, adrenoceptor, dopamine, adenosine, acetylcholine, muscarinic, histamine, metabotropic glutamate receptor, cannabinoid receptor, class A orphans