Protease Inhibitors

Proteases are enzymes that catalyze proteolysis and can be found in all forms of life, even in viruses. The proteolysis process is realized by cleaving peptide bonds within proteins. Proteases control a variety of physiological processes such as immune response, cell cycle, cell death, wound healing, and food digestion. This fact makes proteases an important group of molecular targets for metabolic disease treatment, as well as the treatment of pathogenic diseases caused by bacteria or viruses.

Protease Inhibitors Library is composed of 777 small ligands. The collection includes compounds with activity against metabolic diseases; inhibitors of ACE2 metalloprotease, which is responsible for SARS-CoV-2 cell entry; ligands with broad-scope antiviral activity; antiprotozoal compounds.

Related terms: methionyl aminopeptidase, dipeptidyl peptidase, cathepsin B, monoacylglycerol lipase, MMP2, MMP8, serine protease, MMP13, angiotensin-converting enzyme