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EBCL-0009

Angiogenesis Related Ligands

Angiogenesis is the essential physiological process of the formation of new blood vessels from existing ones, formed earlier at the stage of vasculogenesis. It is a crucial process for the growth and development of the human body, as well as for wound healing by the formation of granulation tissue. Disorders in the angiogenesis-related signaling pathways lead to cancer or cardiovascular diseases. These diseases can be controlled by exogenous angiogenesis activators (cardiovascular) or inhibitors (cancer). Some key activators of angiogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, TGF-β, etc. The angiogenesis inhibitors are angiostatin, endostatin, interferon, platelet factor 4, etc.

Angiogenesis Related Ligands Library consists of 677 small ligands, some representative molecules are given below: TSC359, FLT3 inhibitor; ML106, DYRK1A inhibitor; DB04760, Collagenase 3 inhibitor; Fedratinib, Cyclin-G-associated kinase inhibitor.


Related terms: COX-1 , COX-2, epidermal growth factor, fms related receptor tyrosine kinase, platelet derived growth factor, fibroblast growth factor, AT1 receptor, MMP8

Library image

Representation of the connection between angiogenesis and cancer tumor growth (Created By BioRender.com)

Preplated options

Dry powder/solution (DMSO)Dry powder
Number of compounds677
Comment
Dry powder/solution (DMSO)DMSO
Number of compounds565
Comment

Highlights

Molecule highlight
EBC-00624CAS: 301305-73-7

TCS 359, FLT3 inhibitor EBC-00624

Molecule highlight
EBC-00707CAS: 959489-44-2

ML106, DYRK1A inhibitor EBC-00707

Molecule highlight
EBC-47495CAS: 544678-85-5

DB04760, Collagenase 3 inhibitor EBC-47495

Molecule highlight
EBC-17140CAS: 936091-26-8

Fedratinib, Cyclin-G-associated kinase inhibitor EBC-17140

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All our products are for research purpose only. Any personal or non-scientific use is strictly prohibited.

Note

All the compounds with solubility below 10 mM are shipped as 2 mM solutions.

Product Features

  • A set of 677 angiogenesis relevant molecules with sub-10 micromolar activity coefficient values for HTS/HCS programs.
  • The library is composed of ligands that target all major pharmaceutically relevant angiogenesis targets.
  • Angiogenesis Related Ligands Library covers novel promising preclinical lead compounds, clinical candidates and approved drugs.
  • Calculated structural diversity of the collection: 0.86.
  • Comprehensive documentation with structures, trivial names, synonyms, activity coefficient values, types of action on target and references to original literature.
  • NMR and LCMS validated purity.
  • All the compounds are available in stock for hit follow-up.
  • The library is continuously updated.

Product Details

  • Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
  • Container: 384-well microplates;
  • Storage: - 18 °C;
  • Shipping: Dry ice.

Utility

  • High throughput screening (HTS);
  • High content screening (HCS);
  • Cherry picking.

Library Composition

Name
Occurrence in the library, times

COX-2

32

32

Number of compounds

32

epidermal growth factor receptor

29

29

Number of compounds

29

COX-1

24

24

Number of compounds

24

fms related receptor tyrosine kinase 3

21

21

Number of compounds

21

kinase insert domain receptor

16

16

Number of compounds

16

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