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Signal transduction allows an organism to sense its environment and formulate the proper biochemical response. The proteins responsible for the mediation of information are generally called receptors. The changes induced by ligand binding in a receptor initiate biochemical cascades, known as signaling pathways. These cascades are the key mechanisms for the control of cell growth, proliferation, metabolism, and many other processes. So, a small ligand can interfere with and regulate the cell signal transduction processes, forming an important instrument for modern medicinal chemistry, as well as a therapeutic practice.
Signal Transduction Related Ligands Library contains 890 small ligands, some representative molecules are given below: Selatinib, EGFR/HER-2 inhibitor; XAV-939, Tankyrase1/2 inhibitor; G10, agonist of stimulator of STING; Fedratinib, Broad spectrum kinase inhibitor.
Related terms: epidermal growth factor, Janus kinase, kinase insert domain receptor, aryl hydrocarbon receptor, glycogen synthase kinase, mitogen-activated protein kinase, fibroblast growth factor
Signal transduction pathways in mammalian cell (Created by BioRender.com)
Selatinib, EGFR/HER-2 inhibitor EBC-47120
XAV-939, Tankyrase1/2 inhibitor EBC-11320
G10, agonist of stimulator of STING EBC-12383
Fedratinib, Broad spectrum kinase inhibitor EBC-17140
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NoteAll the compounds with solubility below 10 mM are shipped as 2 mM solutions.
epidermal growth factor receptor
24
24
Number of compounds
24
Janus kinase 2
14
14
Number of compounds
14
kinase insert domain receptor
13
13
Number of compounds
13
Aryl hydrocarbon receptor
13
13
Number of compounds
13
glycogen synthase kinase 3 beta
13
13
Number of compounds
13
mitogen-activated protein kinase 14
13
13
Number of compounds
13
fibroblast growth factor receptor 1
11
11
Number of compounds
11
Janus kinase 1
11
11
Number of compounds
11
tankyrase 2
11
11
Number of compounds
11
Endothelial NOS
11
11
Number of compounds
11
Inducible NOS
10
10
Number of compounds
10
MDM2 proto-oncogene
10
10
Number of compounds
10
mitogen-activated protein kinase 10
10
10
Number of compounds
10
cathepsin B
9
9
Number of compounds
9
Neuronal NOS
9
9
Number of compounds
9
erb-b2 receptor tyrosine kinase 2
8
8
Number of compounds
8
Janus kinase 3
8
8
Number of compounds
8
mitogen-activated protein kinase 8
8
8
Number of compounds
8
glycogen synthase kinase 3 alpha
7
7
Number of compounds
7
tyrosine kinase 2
7
7
Number of compounds
7
neurotrophic receptor tyrosine kinase 1
6
6
Number of compounds
6
tankyrase
6
6
Number of compounds
6
casein kinase 1 delta
6
6
Number of compounds
6
CXCR4
6
6
Number of compounds
6
heat shock protein 90 beta family member 1
6
6
Number of compounds
6
fms related receptor tyrosine kinase 1
5
5
Number of compounds
5
neurotrophic receptor tyrosine kinase 3
5
5
Number of compounds
5
B-Raf proto-oncogene, serine/threonine kinase
5
5
Number of compounds
5
indoleamine 2,3-dioxygenase 1
5
5
Number of compounds
5
fibroblast growth factor receptor 2
5
5
Number of compounds
5
signal transducer and activator of transcription 3
5
5
Number of compounds
5
mitogen-activated protein kinase 9
5
5
Number of compounds
5
AT1 receptor
4
4
Number of compounds
4
casein kinase 1 epsilon
4
4
Number of compounds
4
Caspase 3
4
4
Number of compounds
4
mitogen-activated protein kinase kinase 1
4
4
Number of compounds
4
neurotrophic receptor tyrosine kinase 2
3
3
Number of compounds
3
component of inhibitor of nuclear factor kappa B kinase complex
3
3
Number of compounds
3
fibroblast growth factor receptor 3
3
3
Number of compounds
3
Insulin receptor
3
3
Number of compounds
3
fms related receptor tyrosine kinase 4
3
3
Number of compounds
3
mitogen-activated protein kinase 1
3
3
Number of compounds
3
protein kinase A
3
3
Number of compounds
3
activin A receptor type 1
3
3
Number of compounds
3
casein kinase 1 alpha 1
3
3
Number of compounds
3
SMO
3
3
Number of compounds
3
3-phosphoinositide dependent protein kinase 1
2
2
Number of compounds
2
MET proto-oncogene, receptor tyrosine kinase
2
2
Number of compounds
2
Insulin-like growth factor I receptor
2
2
Number of compounds
2
CaS receptor
2
2
Number of compounds
2
cathepsin L
2
2
Number of compounds
2
cathepsin S
2
2
Number of compounds
2
EP2 receptor
2
2
Number of compounds
2
EPH receptor B4
2
2
Number of compounds
2
erb-b2 receptor tyrosine kinase 4
2
2
Number of compounds
2
MAPK interacting serine/threonine kinase 2
2
2
Number of compounds
2
interleukin 1 receptor associated kinase 4
2
2
Number of compounds
2
mitogen-activated protein kinase kinase 2
2
2
Number of compounds
2
proteasome 20S subunit beta 5
2
2
Number of compounds
2
protein kinase, cAMP-dependent, catalytic, alpha subunit
2
2
Number of compounds
2
Raf-1 proto-oncogene, serine/threonine kinase
2
2
Number of compounds
2
SST3 receptor
2
2
Number of compounds
2
activin A receptor type IL
1
1
Number of compounds
1
advanced glycosylation end-product specific receptor
1
1
Number of compounds
1
AKT serine/threonine kinase 1
1
1
Number of compounds
1
AKT serine/threonine kinase 2
1
1
Number of compounds
1
activin A receptor type 1B
1
1
Number of compounds
1
serine/threonine kinase 4
1
1
Number of compounds
1
AKT serine/threonine kinase 3
1
1
Number of compounds
1
cathepsin H
1
1
Number of compounds
1
EP4 receptor
1
1
Number of compounds
1
fibroblast growth factor receptor 4
1
1
Number of compounds
1
casein kinase 1 gamma 2
1
1
Number of compounds
1
IMPase 1
1
1
Number of compounds
1
tryptophan 2,3-dioxygenase
1
1
Number of compounds
1
inhibitor of nuclear factor kappa B kinase subunit beta
1
1
Number of compounds
1
Interferon-γ receptor
1
1
Number of compounds
1
IP3 kinase A
1
1
Number of compounds
1
KCa3.1
1
1
Number of compounds
1
Liver X receptor-α
1
1
Number of compounds
1
MAPK activated protein kinase 2
1
1
Number of compounds
1
mitogen-activated protein kinase 13
1
1
Number of compounds
1
mitogen-activated protein kinase 11
1
1
Number of compounds
1
calcium/calmodulin-dependent protein kinase II alpha subunit
1
1
Number of compounds
1
macrophage stimulating 1 receptor
1
1
Number of compounds
1
inhibitor of nuclear factor kappa B kinase subunit epsilon
1
1
Number of compounds
1
TANK binding kinase 1
1
1
Number of compounds
1
myosin light chain kinase
1
1
Number of compounds
1
NLRP3
1
1
Number of compounds
1
PAF receptor
1
1
Number of compounds
1
PLCγ2
1
1
Number of compounds
1
proteasome 20S subunit beta 1
1
1
Number of compounds
1
proteasome 20S subunit beta 8
1
1
Number of compounds
1
proteasome 20S subunit beta 9
1
1
Number of compounds
1
proteasome 20S subunit beta 2
1
1
Number of compounds
1
SERCA1
1
1
Number of compounds
1
synaptic vesicle glycoprotein 2A
1
1
Number of compounds
1
transforming growth factor beta receptor 1
1
1
Number of compounds
1
Transforming growth factor β receptor
1
1
Number of compounds
1
transforming growth factor beta receptor 2
1
1
Number of compounds
1
EBCL-0011