Signal Transduction Related Ligands

Signal transduction allows an organism to sense its environment and formulate the proper biochemical response. The proteins responsible for the mediation of information are generally called receptors. The changes induced by ligand binding in a receptor initiate biochemical cascades, known as signaling pathways. These cascades are the key mechanisms for the control of cell growth, proliferation, metabolism, and many other processes. So, a small ligand can interfere with and regulate the cell signal transduction processes, forming an important instrument for modern medicinal chemistry, as well as a therapeutic practice.

Signal Transduction Related Ligands Library contains 890 small ligands, some representative molecules are given below: Selatinib, EGFR/HER-2 inhibitor; XAV-939, Tankyrase1/2 inhibitor; G10, agonist of stimulator of STING; Fedratinib, Broad spectrum kinase inhibitor.

Related terms: epidermal growth factor, Janus kinase, kinase insert domain receptor, aryl hydrocarbon receptor, glycogen synthase kinase, mitogen-activated protein kinase, fibroblast growth factor