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EBCL-0013

Cancer Immunology Related Ligands

Immuno-oncology is a trend in immunotherapy, which is directed at the stimulation of the immune system response against cancer cells. Normally the human immune system destroys cancer cells in the body, but cancer cells adapt and mutate in some cases, successfully camouflaging from the immune system. This fact allows tumors to grow and threaten the organism. Classical cancer immunotherapy agents are modified T-cells that target tumors, or antibody-based species that target the immune checkpoint cascades. However, small molecules acting on intracellular molecular targets, that affect immune response against cancer cells, are also an important tool for cancer immunology.

Cancer Immunology Related Ligands Library contains 1749 small ligands, some representative molecules are given below: Gefapixant, P2X3 receptor antagonist; ABX-1431, MAG lipase inhibitor; TGX115, PI3 kinase inhibitor; Ticagrelor, P2Y12 platelet inhibitor.


Related terms: A1 receptor, epoxide hydrolase, A2A, A3 receptor, fatty acid amide hydrolase, acetylcholinesterase, butyrylcholinesterase, carboxylesterase, Janus kinase

Library image

Immunosuppressive cells and related molecular targets in tumor microenvironment (Created by BioRender.com)

Preplated options

Dry powder/solution (DMSO)Dry powder
Number of compounds1749
Comment
Dry powder/solution (DMSO)DMSO
Number of compounds1763
Comment

Highlights

Molecule highlight
EBC-08759CAS: 1015787-98-0

Gefapixant, P2X3 receptor antagonist EBC-08759

Molecule highlight
EBC-07964CAS: 1446817-84-0

ABX-1431, MAG lipase inhibitor EBC-07964

Molecule highlight
EBC-12379CAS: 351071-62-0

TGX115, PI3 kinase inhibitor EBC-12379

Molecule highlight
EBC-12279CAS: 274693-27-5

Ticagrelor, P2Y12 platelet inhibitor EBC-12279

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All our products are for research purpose only. Any personal or non-scientific use is strictly prohibited.

Note

All the compounds with solubility below 10 mM are shipped as 2 mM solutions.

Product Features

  • A set of 1749 cancer immunology relevant molecules with sub-10 micromolar activity coefficient values for HTS/HCS programs.
  • The library is composed of ligands that target all major pharmaceutically relevant cancer immunology targets.
  • Cancer Immunology Related Ligands Library covers novel promising preclinical lead compounds, clinical candidates and approved drugs.
  • Calculated structural diversity of the collection: 0.87.
  • Comprehensive documentation with structures, trivial names, synonyms, activity coefficients values, types of action on target and references to original literature.
  • NMR and LCMS validated purity.
  • All the compounds are available in stock for hit follow-up.
  • The library is continuously updated.

Product Details

  • Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
  • Container: 384-well microplates;
  • Storage: - 18 °C;
  • Shipping: Dry ice.

Utility

  • High throughput screening (HTS);
  • High content screening (HCS);
  • Cherry picking.

Library Composition

Name
Occurrence in the library, times

A1 receptor

61

61

Number of compounds

61

epoxide hydrolase 2

57

57

Number of compounds

57

A2A receptor

54

54

Number of compounds

54

A3 receptor

46

46

Number of compounds

46

Fatty acid amide hydrolase

40

40

Number of compounds

40

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