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The cell cycle is a sequence of events that occur in a cell in the preparation for cell division. It is a two-step process: interphase and mitotic (M) phase. The interphase step is divided into three different phases: G1 phase, S phase, and G2 phase. Cell cycle checkpoints are integral components of DNA repair that coordinate the restoration of DNA structure. When some genes (such as the cell cycle inhibitors, RB, p53, etc) mutate, they may cause the cell uncontrollable proliferation, which leads to tumor formation. At the same time, the cells which are actively undergoing the cell cycle can be efficiently targeted by cancer therapy. Their DNA is exposed during the division and hence susceptible to damage by drugs. It makes molecular targets related to the cell cycle attractive for cancer medicinal chemistry research.
Library of Cell Cycle Related Ligands contains 448 small ligands, some representative molecules are given below: LDC000067, Cdl9 inhibitor; HLM-008182, Plk3 inhibitor; CDK12-In-2, Cdk12 and Cdk13 inhibitor; Palbociclib, CDK2, CDK4, CDK6 and CDK7 inhibitor.
Related terms: poly(ADP-ribose) polymerase, aurora kinase, MDM2 proto-oncogene, cyclin dependent kinase, tankyrase, checkpoint kinase, polo like kinase, CXCR4
Cell cycle and related molecular targets (Created by BioRender.com)
LDC000067, Cdl9 inhibitor, EBC-46039
HLM-008182, Plk3 inhibitor, EBC-07439
CDK12-In-2, Cdk12 and Cdk13 inhibitor, EBC-13127
Palbociclib, CDK2, CDK4, CDK6 and CDK7 inhibitor, EBC-17116
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NoteAll the compounds with solubility below 10 mM are shipped as 2 mM solutions.
poly(ADP-ribose) polymerase 1
34
34
Number of compounds
34
aurora kinase A
12
12
Number of compounds
12
MDM2 proto-oncogene
12
12
Number of compounds
12
cyclin dependent kinase 2
11
11
Number of compounds
11
tankyrase 2
11
11
Number of compounds
11
cyclin dependent kinase 4
9
9
Number of compounds
9
tankyrase
9
9
Number of compounds
9
aurora kinase B
8
8
Number of compounds
8
cyclin dependent kinase 1
8
8
Number of compounds
8
cyclin dependent kinase 7
8
8
Number of compounds
8
checkpoint kinase 2
7
7
Number of compounds
7
polo like kinase 1
7
7
Number of compounds
7
cyclin dependent kinase 6
7
7
Number of compounds
7
cyclin dependent kinase 5
6
6
Number of compounds
6
NIMA related kinase 2
6
6
Number of compounds
6
polo like kinase 3
6
6
Number of compounds
6
CXCR4
6
6
Number of compounds
6
cyclin dependent kinase 8
5
5
Number of compounds
5
cyclin dependent kinase 9
5
5
Number of compounds
5
poly(ADP-ribose) polymerase 2
4
4
Number of compounds
4
aurora kinase C
3
3
Number of compounds
3
cyclin dependent kinase 3
3
3
Number of compounds
3
NIMA related kinase 1
3
3
Number of compounds
3
polo like kinase 2
3
3
Number of compounds
3
ATM serine/threonine kinase
2
2
Number of compounds
2
ATR serine/threonine kinase
2
2
Number of compounds
2
polo like kinase 4
2
2
Number of compounds
2
cyclin dependent kinase 16
2
2
Number of compounds
2
histone H3 associated protein kinase
2
2
Number of compounds
2
NIMA related kinase 3
2
2
Number of compounds
2
TTK protein kinase
2
2
Number of compounds
2
cyclin dependent kinase 12
2
2
Number of compounds
2
cyclin dependent kinase 17
2
2
Number of compounds
2
NIMA related kinase 4
1
1
Number of compounds
1
NIMA related kinase 6
1
1
Number of compounds
1
cell division cycle 7
1
1
Number of compounds
1
NIMA related kinase 11
1
1
Number of compounds
1
cyclin dependent kinase 13
1
1
Number of compounds
1
poly (ADP-ribose) polymerase 3
1
1
Number of compounds
1
EBCL-0014