Cell Cycle Related Ligands

The cell cycle is a sequence of events that occur in a cell in the preparation for cell division. It is a two-step process: interphase and mitotic (M) phase. The interphase step is divided into three different phases: G1 phase, S phase, and G2 phase. Cell cycle checkpoints are integral components of DNA repair that coordinate the restoration of DNA structure. When some genes (such as the cell cycle inhibitors, RB, p53, etc) mutate, they may cause the cell uncontrollable proliferation, which leads to tumor formation. At the same time, the cells which are actively undergoing the cell cycle can be efficiently targeted by cancer therapy. Their DNA is exposed during the division and hence susceptible to damage by drugs. It makes molecular targets related to the cell cycle attractive for cancer medicinal chemistry research.

Library of Cell Cycle Related Ligands contains 864 small ligands, some representative molecules are given below: LDC000067, Cdl9 inhibitor; HLM-008182, Plk3 inhibitor; CDK12-In-2, Cdk12 and Cdk13 inhibitor; Palbociclib, CDK2, CDK4, CDK6 and CDK7 inhibitor.

Related terms: poly(ADP-ribose) polymerase, aurora kinase, MDM2 proto-oncogene, cyclin dependent kinase, tankyrase, checkpoint kinase, polo like kinase, CXCR4