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EBCL-0055

Natural Product Derivatives

Building on the legacy of nature’s medicine chest, our Library of Natural Product Derivatives and Analogs offers a powerful expansion of structural diversity beyond native compounds. These molecules are synthetically modified or inspired by known natural scaffolds, enhancing their pharmacokinetic properties, stability, and target specificity while preserving the unique biological richness of their origins.


Our collection of 30480 expertly designed compounds includes semi-synthetic derivatives, analogs, and bioisosteric variants aimed at improving efficacy and minimizing toxicity. This library bridges the gap between traditional natural products and modern medicinal chemistry—making it an ideal source for lead optimization, SAR studies, and phenotypic screening.


With annotated data of predicted targets, and drug-likeness, this library enables focused discovery in various areas. Whether you're seeking novel mechanisms or known frameworks with improved profiles, our library of analogs is a rich, rationally built resource tailored for translational research.


Related terms: natural products, modified natural products, small molecule derivatives, nature medicine, traditional medicine

Library image

Preplated options

Dry powder/solution (DMSO)Dry powder
Number of compounds30480
Comment

Highlights

Molecule highlight
EBC-49036CAS: 68483-33-0

Apyramide is an anti-inflammatory agent and behaves as a prodrug of indomethacin.

Molecule highlight
EBC-03507CAS: 882-09-7

Clofibric acid is an agonist of the PPAR-α receptor in muscle, liver, and other tissues.

Molecule highlight
EBC-12795CAS: 518-28-5

Podofilox is a topical agent used for the treatment of external genital warts and perianal warts.

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Disclaimer

All our products are for research purpose only. Any personal or non-scientific use is strictly prohibited.

Note

All the compounds with solubility below 10 mM are shipped as 2 mM solutions.

Product Features

Product Features:

  • Library of Natural Product Derivatives is a set of 30480 bioactive molecules for HTS/HCS programs.
  • Comprehensive documentation with structures, trivial names and flavour, odour and taste profiles.
  • NMR and LCMS validated purity.
  • Calculated structural diversity of the collection: 0.84
  • All the compounds are available in stock for hit follow-up.
  • The library is continuously updated.

Product Details

  • Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
  • Container: 384-well microplates;
  • Storage: - 18 °C;
  • Shipping: Dry ice.

Utility

  • High throughput screening (HTS);
  • High content screening (HCS);
  • Cherry picking.