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EBCL-0044

Traditional Chinese Medicine Active Compounds

The Traditional Chinese Medicine Active Compound Library is a collection of bioactive compounds, bridging ancient medicinal wisdom with modern scientific exploration. This extensive library provides access to a wide array of compounds that influence critical biological pathways, with potential applications in areas such as inflammation, oxidative stress, metabolic regulation, neuroprotection, and more.

Among the well-known compounds are:

- Curcumin, recognized for its potent anti-inflammatory and antioxidant properties. It modulates key pathways like NF-κB and MAPK, contributing to the reduction of inflammation and oxidative damage. It is also potentially active in preventing neurodegenerative diseases like Alzheimer’s.

- Resveratrol is a widely researched antioxidant, which regulates pathways such as SIRT1 and AMPK. Its broad therapeutic potential includes aging, cardioprotection, cancer prevention, and metabolic regulation.

- Quercetin, a flavonoid found in many fruits and vegetables, is known for its ability to regulate inflammation by inhibiting enzymes like COX-2 and activating the Nrf2 antioxidant pathway. It has been studied for its protective effects against oxidative stress and potential cancer-preventive properties.

- Theobromine, a compound from cacao, acts as a mild stimulant with cardiovascular benefits. It influences adenosine receptors and serves as a vasodilator, enhancing blood flow, and is of great interest for its potential in mood regulation and heart health.

The TCM Active Compound Library integrates solubility, pathway targeting, and biological activity insights, making it invaluable resource for researchers exploring the pharmacological potential of TCM-derived compounds in modern medicine.


Related terms: chinese medicine, alternative medicine, natural products, inflammation, antioxidants, adenosine receptors, NF-κB, COX-2, MAP kinase

Library image

Preplated options

Dry powder/solution (DMSO)Dry powder
Number of compounds494
Comment
Dry powder/solution (DMSO)DMSO
Number of compounds815
Comment

Highlights

Molecule highlight
EBC-44410CAS: 477-90-7

Bergenin is a glycoside and a major constituent of Peltophorum plants and has diverse biological activities.

Molecule highlight
EBC-46181CAS: 1196-01-6

(-)-Verbenone is a natural terpene in leaves of the tree, Suregada zanzibariensis Verdc.

Molecule highlight
EBC-47140CAS: 56293-29-9

Aloperine is an alkaloid found in the roots of S. flavescens with diverse biological activities.

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Disclaimer

All our products are for research purpose only. Any personal or non-scientific use is strictly prohibited.

Note

All the compounds with solubility below 10 mM are shipped as 2 mM solutions.

Product Features

  • TCM Active Compound Library is a collection of 2797 compounds extracted from Traditional Chinese Medicine mixtures and ingredients and can be used for HTS/HCS programs.
  • Calculated structural diversity of the collection: 0.9
  • Comprehensive documentation with structures, trivial names, synonyms and references to original drugs.
  • NMR and LCMS validated purity.
  • All the compounds are available in stock for hit follow-up.
  • The library is continuously updated.

Product Details

  • Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
  • Container: 384-well microplates;
  • Storage: - 18 °C;
  • Shipping: Dry ice.

Utility

  • High throughput screening (HTS);
  • High content screening (HCS);
  • Cherry picking.