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EBC provides a large collection of stock compounds with annotated biological activity, allowing to perform target-oriented, activity type and value-filtered searches, as well as a search of main target activities. We offer you all compounds in a suitable format: dry powder or pre-plated. Furthermore, we provide a pre-plated list of individual compounds, so you just pick the required compounds, choose the type of plate, and enjoy your day waiting for our response. Also, we can provide you with all available approved information about biological activity for the desired set of compounds from your individual list.
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EBC-11389
CAS: 808118-40-3
Roxadustat (FG-4592) is a hypoxia-inducible factor prolyl hydroxylase enzyme (HIF-PH) inhibitor.
Formula
C19H16N2O5
Smiles
CC1=NC(C(=O)NCC(O)=O)=C(O)C2=CC=C(OC3=CC=CC=C3) C=C12 |c:20,22,t:1,10,13,15,18,25
FDA approved
YES
Name
Roxadustat
Target
egl-9 family hypoxia inducible factor 2 | egl-9 family hypoxia inducible factor 1 | egl-9 family hypoxia inducible factor 3
Target action
Inhibitor | Inhibitor | Inhibitor
Activity and values
IC50 - 0.002 μM | Ki (inhibition constant) - 0.009 μM | IC50 - 0.005 μM
Target references
Biosci. Rep., 2017, vol. 37, # 3 | Biosci. Rep., 2017, vol. 37, # 3 | Biosci. Rep., 2017, vol. 37, # 3
NCT ID
NCT02161224 | NCT02161796 | NCT05810311