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Enamine Bioactive Compounds (EBC) is a new branch of Enamine Discovery Services, dedicated to sourcing and delivering fully annotated bioactive chemical compounds. SMART Search engine allows target-oriented, activity type and value filtered searches, as well as a search of main target activities.

How we work

EBC provides a large collection of stock compounds with annotated biological activity, allowing to perform target-oriented, activity type and value-filtered searches, as well as a search of main target activities. We offer you all compounds in a suitable format: dry powder or pre-plated. Furthermore, we provide a pre-plated list of individual compounds, so you just pick the required compounds, choose the type of plate, and enjoy your day waiting for our response. Also, we can provide you with all available approved information about biological activity for the desired set of compounds from your individual list.

Work block image one
01

Our pre-plated
compound set

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Your customized
compound set

Example of the
response to the data request

Molecule ticket

EBC-11389

CAS: 808118-40-3

Roxadustat (FG-4592) is a hypoxia-inducible factor prolyl hydroxylase enzyme (HIF-PH) inhibitor.

Formula

C19H16N2O5

Smiles

CC1=NC(C(=O)NCC(O)=O)=C(O)C2=CC=C(OC3=CC=CC=C3) C=C12 |c:20,22,t:1,10,13,15,18,25

FDA approved

YES

Name

Roxadustat

Target

egl-9 family hypoxia inducible factor 2 | egl-9 family hypoxia inducible factor 1 | egl-9 family hypoxia inducible factor 3

Target action

Inhibitor | Inhibitor | Inhibitor

Activity and values

IC50 - 0.002 μM | Ki (inhibition constant) - 0.009 μM | IC50 - 0.005 μM

Target references

Biosci. Rep., 2017, vol. 37, # 3 | Biosci. Rep., 2017, vol. 37, # 3 | Biosci. Rep., 2017, vol. 37, # 3

NCT ID

NCT02161224 | NCT02161796 | NCT05810311

Bioactive compounds
purchase form

Title

First name *
Last name *
Company name *
Email *
Inquiry description *
Give as many biological details of your study as possible, this would help our team to select better quality compounds set for your needs
Targets/Target families *
Please type N/A if target description is irrelevant to your study

Required compound format *

Required compound purity, % *
Selecting a custom purity option in many cases will lead to increased shipment time and will affect pricing.

Preferred activity range, uM *
Please type N/A if compound activity is an unimportant factor for your study, for instance, you opt for clinically approved compounds.

Preferred selectivity:
Please describe selectivity if applicable.
Approximate expected set size
Please type the number of compounds grounding on your research plan and budget.
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