RNA-Binding Protein Ligands

The Library of RNA-Binding Protein Ligands is a comprehensive collection of 316 ligands designed to target key RNA-binding proteins (RBPs) involved in crucial cellular processes. This library contains pre-synthesized ligands, ready to support a wide range of experimental applications in RNA biology and drug discovery. Each ligand in the collection is meticulously characterized, providing in-depth data on target interactions and biochemical properties, ensuring researchers have the critical information needed to drive meaningful discoveries in RNA-related pathways. This ready-to-use resource is ideal for advancing studies in translation regulation, RNA metabolism, gene expression control, and immune responses.

The library aims to accelerate innovation in fundamental research and therapeutic development, empowering researchers to explore the dynamic roles of RNA-binding proteins in disease and biology.

Related terms: RNA-binding, Lysine-tRNA ligase, Nucleophosmin, Polyadenylate-binding protein.

Preplated options

Dry powder/solution (DMSO)Dry powder

Number of compounds316

Comment

Dry powder/solution (DMSO)DMSO

Number of compounds29

Comment

Highlights

EBC-08851CAS: 790717-09-8

2-(3-Oxobenzo[d]isothiazol-2(3H)-yl)-N-(1-adamantyl)acetamide shows inhibitory activity against sortase A.

EBC-00690CAS: 183321-74-6

Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase.

EBC-218031CAS: 377090-84-1

SU9516 is a potent and selective CDK2 inhibitor, with an IC50 of 17.3 nM. It also inhibits Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1.

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Disclaimer

All our products are for research purpose only. Any personal or non-scientific use is strictly prohibited.

Note

All the compounds with solubility below 10 mM are shipped as 2 mM solutions.

Product Features

The RNA-Binding Protein Ligand Library is a curated set of 316 small molecules with well-documented activity coefficient values for HTS/HCS programs.
Calculated structural diversity of the collection: 0.84.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.

Product Details

Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.

Utility

High throughput screening (HTS);
High content screening (HCS);
Cherry picking.

Library Composition

Name

Occurrence in the library, times

Polyadenylate-binding protein 1

261

Number of compounds

261

Bromodomain adjacent to zinc finger domain protein 2A

Number of compounds

Histone-lysine N-methyltransferase EZH2

Number of compounds

Interferon-induced, double-stranded RNA-activated protein kinase

Number of compounds

Bifunctional glutamate/proline--tRNA ligase

Number of compounds

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