UK-383367

UK-383367, also referred to as UK 383367 and PF-04171426, is a selective small molecule widely used in neuroscience and receptor pharmacology research. Identified under CAS 348622-88-8, this compound is associated with studies of dopamine receptor modulation, particularly in relation to central nervous system signaling pathways. UK-383367 Pfizer programs have contributed to its recognition as a reference molecule in dopaminergic research.

Researchers often examine UK-383367 chemical structure to better understand its receptor binding profile and selectivity. Additionally, UK-383367 molecular weight is a key parameter during experimental planning, influencing compound preparation, dosing strategies, and reproducibility across assay systems.

Application of UK-383367

Application UK-383367 is mainly focused on studies involving dopamine receptor activity, especially D1 receptor-mediated signaling. It is commonly used in neuropharmacology research to evaluate receptor activation, intracellular signaling cascades, and functional outcomes in neuronal systems.

• investigation of dopamine receptor agonism in CNS models
• analysis of signaling pathways related to cognition and motor function
• screening and validation of dopaminergic compounds

Its well-defined pharmacological profile supports its use in both mechanistic research and early-stage drug discovery workflows targeting neurological disorders.

In Vitro

In vitro, UK-383367 demonstrates selective activity toward dopamine receptors, making it suitable for receptor binding assays and functional cellular studies. It is often applied in systems designed to measure second messenger responses such as cAMP production, providing insight into receptor activation dynamics.

These controlled experimental conditions allow researchers to isolate the compound’s effects and compare its activity with other dopaminergic agents.

In Vivo

In vivo studies of UK-383367 have explored its effects on behavioral and neurological responses linked to dopamine signaling. It has been used in animal models to investigate motor activity, cognitive function, and receptor-mediated physiological changes.

Such studies highlight its relevance in translational neuroscience, although experimental outcomes depend on study design, dosing, and biological system selection.

Biochemical and Physiological Actions

The primary biochemical action of UK-383367 involves activation of dopamine D1 receptors, which play a key role in regulating neuronal signaling, synaptic plasticity, and behavioral responses. This receptor-specific activity enables detailed investigation of dopaminergic pathways without significant interference from other receptor systems.

From a physiological perspective, UK-383367 supports research into processes such as learning, memory, and motor coordination, all of which are influenced by dopamine signaling in the brain.

Features and benefits of UK-383367

UK-383367 offers a combination of selectivity and experimental reliability, making it a valuable tool in neuroscience research. When sourced as EBC-497101, it is supported by quality control and analytical validation, ensuring consistency across studies.

• high selectivity for dopamine receptor targets
• reliable performance in in vitro and in vivo models
• relevance for neuroscience and pharmacological research applications

As part of a comprehensive portfolio of bioactive compounds, UK-383367 enables researchers to explore complex signaling pathways and advance experimental workflows with confidence.