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Product details:
CAS
1950634-92-0
Purity
95%
dBET6 is a cell-permeable chemical cereblon-based degrader of BET bromodomain protein (nanomolar degradation of BRD4, BRD3 and BRD2). dBET6 was well tolerated in 2-weeks mouse in vivo xenograpf model reported in the literature and show antitumor activity.
Properties
Name
dBET6
Smiles
CC1=NN=C2[C@H](CC(=O)NCCCCCCCCNC(=O)COC=3C=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C43)N=C(C=6C(C)=C(C)SC6N12)C=7C=CC(Cl)=CC7
Targets
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Target name
Target pX
Target action
doi
SDS
dBET6
No data available
The compound has purity validated by NMR and/or LCMS methods.
1 mg
$110
2 mg
$112
5 mg
$120
10 mg
$133
15 mg
$186
20 mg
$238
25 mg
$304
30 mg
$347
35 mg
$383
40 mg
$428
45 mg
$472
50 mg
$524
75 mg
$678
100 mg
$POA
Quantity
1
Total amount
$ 120
dBET6
No data available
The compound has purity validated by NMR and/or LCMS methods.
Target activity features
It should be emphasized that the product may be active against a larger number of targets than shown on the card. The information represented here refers to the targets with the largest value of pX or the targets with ΔpX less than 1.5 from the largest pX value.