PF-05089771 p-toluene sulfonate, also known as PF-05089771 and PF 05089771, is a selective small molecule developed for research in ion channel pharmacology. Identified under CAS 1430806-04-4, this compound is widely associated with studies targeting voltage-gated sodium channels, particularly NaV1.7, which plays a central role in pain signaling pathways. PF-05089771 p-toluene sulfonate Pfizer programs contributed to its recognition as a reference compound in analgesic research and neurobiology.
Researchers often examine PF-05089771 p-toluene sulfonate chemical structure to better understand its selectivity and binding affinity toward sodium channel subtypes. In addition, PF-05089771 p-toluene sulfonate molecular weight is a key parameter used in assay preparation, supporting accurate dosing and consistency across experimental systems.
Application of PF-05089771 p-toluene sulfonate
Application PF-05089771 p-toluene sulfonate is primarily focused on studies involving pain mechanisms, neuronal excitability, and sodium channel modulation. Its selectivity toward NaV1.7 makes it particularly useful in research aimed at identifying non-opioid approaches to pain management.
- investigation of NaV1.7 channel inhibition in sensory neurons
- evaluation of pain signaling pathways in preclinical models
- screening of ion channel modulators in neuroscience research
These applications position PF-05089771 p-toluene sulfonate as a valuable compound in both mechanistic studies and drug discovery workflows targeting neurological disorders.
Biochemical and Physiological Actions
The primary biochemical action of PF-05089771 p-toluene sulfonate involves selective inhibition of voltage-gated sodium channels, particularly NaV1.7. This channel is critically involved in the initiation and transmission of pain signals in peripheral neurons. By modulating its activity, PF-05089771 influences neuronal firing and reduces excitability in pain-related pathways.
From a physiological perspective, this effect supports research into nociception, neuropathic pain, and sensory signal processing. The compound allows researchers to isolate specific channel-driven mechanisms without significant interference from other sodium channel subtypes, improving the precision of experimental outcomes.
Features and benefits of PF-05089771 p-toluene sulfonate
PF-05089771 p-toluene sulfonate offers a well-characterized profile for ion channel research, making it suitable for advanced pharmacological studies. When provided as EBC-764076, it is supported by analytical validation and quality control, ensuring reproducibility and reliability.
- high selectivity for NaV1.7 sodium channel targets
- relevance for pain research and neuroscience applications
- consistent quality supported by validated analytical data
As part of a broader portfolio of bioactive molecules, PF-05089771 supports efficient investigation of ion channel function and contributes to the development of targeted therapeutic strategies in pain management research.
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