CP-100356 hydrochloride

CP-100356 hydrochloride, also known as cp-100356 and PF-01731298, is a selective inhibitor widely used in pharmacological research focused on drug transport and multidrug resistance mechanisms. Identified under CAS 142715-48-8, this compound is recognized for its ability to modulate P-glycoprotein activity, making it relevant in studies of drug absorption and distribution. CP-100356 hydrochloride Pfizer development programs contributed to its use as a reference tool in transporter-related research.

Researchers often review CP-100356 hydrochloride chemical structure to better understand its interaction with efflux transporters and membrane proteins. In addition, CP-100356 hydrochloride molecular weight is an important parameter in experimental planning, supporting accurate preparation of solutions and consistency across assays.

Application of CP-100356 Hydrochloride

Application CP-100356 hydrochloride is primarily associated with studies of P-glycoprotein inhibition and drug transport across biological membranes. It is frequently used in research where understanding compound permeability and resistance mechanisms is essential.

• evaluation of P-glycoprotein-mediated drug efflux
• investigation of blood-brain barrier transport mechanisms
• optimization of drug delivery and bioavailability studies

Its selectivity makes cp-100356 a useful tool in screening workflows and in studies aimed at improving pharmacokinetic profiles of candidate molecules.

In Vitro

In vitro, CP-100356 hydrochloride is commonly applied in cell-based assays to assess transporter inhibition and intracellular accumulation of compounds. It enables researchers to measure changes in drug retention within cells and to evaluate the role of efflux pumps in limiting compound efficacy.

These assays are particularly valuable in oncology and central nervous system research, where transporter activity significantly influences therapeutic outcomes.

In Vivo

In vivo studies of CP-100356 hydrochloride focus on its ability to enhance drug penetration by inhibiting transporter-mediated efflux. It has been used in animal models to examine how modulation of P-glycoprotein affects tissue distribution, especially in the brain.

Such studies support translational research by providing insights into how transporter inhibition can improve drug exposure in target tissues.

Biochemical and Physiological Actions

The primary biochemical action of CP-100356 hydrochloride involves inhibition of P-glycoprotein, a key transporter responsible for limiting intracellular accumulation of many compounds. By blocking this efflux mechanism, CP-100356 hydrochloride allows increased retention of substrates within cells.

Physiologically, this effect is important in understanding drug resistance and distribution, particularly in tissues protected by biological barriers such as the blood-brain barrier.

Features and benefits CP-100356 Hydrochloride

CP-100356 hydrochloride provides a well-characterized approach to studying transporter-related processes, making it valuable for both basic and applied research. When sourced as EBC-497105, it is supported by quality control and analytical validation.

• selective inhibition of P-glycoprotein for targeted research applications
• useful tool for studying drug resistance and transport mechanisms
• applicable in both in vitro and in vivo experimental models

As part of a broader portfolio of bioactive compounds, CP-100356 hydrochloride supports efficient investigation of drug transport pathways, helping researchers refine experimental strategies and improve understanding of compound behavior in biological systems.