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Product details:
CAS
1257051-63-0
Purity
95%
THPP-1 is a high quality, selective and potent probe to study PDE10A inhibition in vitro or in vivo. It demonstrated in vivo target engagement and efficacy at a dose (10 mg/kg) that is well tolerated in rats.
Properties
Name
THPP-1
Smiles
COCCOC=1N=C(N=C2CCN(CC12)C(=O)C=3N=CN4C=CC=CC34)C=5C=CC(Cl)=NC5
Targets
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Target name
Target pX
Target action
doi
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (isoform PDE10A2)
9.05
Inhibitor
No records
No data available
The compound has purity validated by NMR and/or LCMS methods.
1 mg
$100
2 mg
$149
5 mg
$298
10 mg
$515
15 mg
$624
20 mg
$733
25 mg
$892
30 mg
$1050
35 mg
$1209
40 mg
$1367
45 mg
$1466
50 mg
$1565
75 mg
$2080
100 mg
$POA
Quantity
1
Total amount
$ 298
No records
No data available
The compound has purity validated by NMR and/or LCMS methods.
Target activity features
It should be emphasized that the product may be active against a larger number of targets than shown on the card. The information represented here refers to the targets with the largest value of pX or the targets with ΔpX less than 1.5 from the largest pX value.