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Product details:
CAS
1226443-41-9
Purity
95%
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
Properties
Name
HQ461
Smiles
CC1=CN=C(NC(=O)CC2=CSC(NC=3C=CC=C(C)N3)=N2)S1
Targets
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SDS
No records
No data available
The compound has purity validated by NMR and/or LCMS methods.
1 mg
$53
2 mg
$54
5 mg
$55
10 mg
$66
15 mg
$73
20 mg
$81
25 mg
$90
30 mg
$100
35 mg
$108
40 mg
$116
45 mg
$122
50 mg
$136
75 mg
$208
100 mg
$POA
Quantity
1
Total amount
$ 55
No records
No data available
The compound has purity validated by NMR and/or LCMS methods.
Target activity features
It should be emphasized that the product may be active against a larger number of targets than shown on the card. The information represented here refers to the targets with the largest value of pX or the targets with ΔpX less than 1.5 from the largest pX value.