Maraviroc is a well-characterized small molecule used in antiviral and receptor biology research, especially in studies centered on CCR5-mediated viral entry. In scientific catalogs and procurement systems, it is commonly identified by CAS 376348-65-1 and 376348-65-1. Researchers also search maraviroc, maraviroc structure, maraviroc chemical structure, maraviroc Pfizer, and Pfizer Maraviroc when matching literature references with supplier documentation and analytical records. According to supplier and regulatory sources, Maraviroc molecular formula is C29H41F2N5O and its molecular weight is 513.67. These descriptors are important not only for registration and quality control, but also for confirming compound identity before screening, validation, or comparative testing workflows begin.
Application of Maraviroc
In research settings, maraviroc is used in HIV entry studies, chemokine receptor signaling, antiviral screening, and host-pathogen interaction models. Its main value comes from its role as a selective CCR5 antagonist, which makes it relevant for experiments designed to examine receptor-dependent viral fusion, entry inhibition, and cellular susceptibility to R5-tropic HIV-1 strains. This also explains why searches such as buy maraviroc, maraviroc buy, maraviroc buy online, maraviroc cost, and buy maraviroc often appear alongside technical terms - investigators are usually evaluating both sourcing options and biological relevance before selecting a material for research use.
In Vitro
In vitro, maraviroc shows potent antagonist activity at CCR5 across multiple cell-based assay systems. Selleck reports inhibitory activity in HeLa-P4, TZM-bl, PM1, HOS, MOLT4, and other models, with low nanomolar to sub-nanomolar values in assays measuring cell-cell fusion, viral infectivity, ligand displacement, and calcium influx. These data make maraviroc useful for researchers investigating the relationship between CCR5 blockade and reduced HIV-1 entry, especially when a study requires a reference compound with extensive assay documentation and a well-recognized mechanism.
In Vivo
In vivo relevance for maraviroc is tied to its established use in HIV-focused pharmacology and its broader value in translational antiviral research. Regulatory and supplier sources describe it as an antiretroviral agent used in the treatment of HIV infection, with activity specifically linked to CCR5-tropic HIV-1. For research teams, this creates a strong bridge between cell-based findings and disease-relevant biological context, which is often essential when selecting a molecule for mechanistic follow-up or pathway-based validation.
Biochemical and Physiological Actions
Biochemically, maraviroc binds selectively to the human CCR5 receptor and blocks the interaction between CCR5 and HIV-1 gp120, thereby preventing viral entry into host cells. DrugBank and other reference sources describe it as a small molecule CCR5 co-receptor antagonist rather than a direct antiviral enzyme inhibitor. Physiologically, this means its activity depends on interrupting receptor-mediated entry of CCR5-tropic HIV-1, while CXCR4-tropic strains are not affected in the same way. This mechanism is one of the main reasons maraviroc structure and maraviroc chemical structure remain important search terms in both research and sourcing environments.
Features and Benefits of Maraviroc
- Clearly defined identifiers, including CAS 376348-65-1, Maraviroc molecular formula, and searchable structural data
- Established CCR5 antagonist activity relevant for HIV entry, receptor biology, and antiviral screening studies
- Strong fit for laboratories comparing maraviroc Pfizer and Pfizer Maraviroc with other entry-focused reference compounds
For EBC-27258, maraviroc offers a practical combination of structural clarity, well-documented in vitro performance, and high relevance for modern antiviral research programs that depend on traceable compounds and mechanism-based selection.
