Aztreonam

About Aztreonam (CAS 78110-38-0)

Aztreonam is a synthetic monobactam antibiotic widely used in antibacterial research focused on Gram-negative aerobic pathogens. In scientific catalogs and procurement systems, it is commonly identified by CAS 78110-38-0 and 78110-38-0. Researchers also search aztreonam, aztreonam structure, aztreonam chemical structure, Pfizer aztreonam, and aztreonam Pfizer when aligning internal compound records with published data and supplier documentation. According to technical supplier information, Aztreonam molecular formula is C13H17N5O8S2 and its molecular weight is 435.43, making structural verification especially important for teams comparing analytical data, reference materials, and product specifications.

Application of Aztreonam

In research settings, aztreonam is applied in microbiology, anti-infective screening, beta-lactam resistance studies, and host-pathogen interaction models. Its relevance comes from a well-established activity profile against Gram-negative aerobic bacteria and from its value as a reference molecule in studies of antibiotic stability and susceptibility. Because it is a recognized antibacterial tool compound, aztreonam is useful in workflows that examine monotherapy effects, combination responses, and the relationship between bacterial burden and cellular protection in infection-related systems. This makes it suitable for discovery teams that need a defined and traceable compound for mechanism-oriented antibacterial research.

Biological Activity

Supplier reference pages describe aztreonam as active against Gram-negative aerobic bacterial infection models and note its use as a bacterial chemical in research. Mechanistic summaries further report that the compound can reduce colony-forming units in selected strains and, in some cystic fibrosis airway cell models, lower biofilm burden while helping preserve monolayer integrity. These details matter for product-oriented content because researchers reviewing aztreonam structure and aztreonam chemical structure are often also checking whether the biological profile matches infection, resistance, or biofilm-related applications relevant to their assay design.

Biochemical and Physiological Actions

At the biochemical level, aztreonam belongs to the beta-lactam class and is notable for its interactions with beta-lactamases. Selleck’s technical summary states that aztreonam is hydrolyzed at measurable rates by selected class A beta-lactamases, while remaining highly stable to the common class C cephalosporinase produced by Citrobacter freundii and by acting as both a competitive and time-dependent inhibitor of that enzyme. The same source also notes synergistic effects when combined with clindamycin in certain bacterial settings. Together, these properties make aztreonam relevant for studies of enzyme stability, resistance mechanisms, and antibacterial combination strategies.

Features and Benefits of Aztreonam

• Clearly defined identifiers, including CAS 78110-38-0, Aztreonam molecular formula, and documented structural data
• Recognized activity in Gram-negative antibacterial research and beta-lactamase-focused studies
• Useful for screening, reference comparison, biofilm-related work, and combination-response experiments

For EBC-27089, aztreonam offers a strong combination of technical clarity and research relevance. Its established antibacterial profile, documented enzyme-related behavior, and searchable identity across supplier systems support confident selection for microbiology and anti-infective discovery workflows.