PF573228 is a well-known research compound used in studies of cell adhesion, migration, mechanotransduction, and kinase signaling. In catalog and procurement workflows, it is also searched as PF-00573228 and CAS 869288-64-2. Published supplier data consistently describe it as a focal adhesion kinase inhibitor with defined technical identifiers, which makes it useful for teams that need a traceable reference molecule for assay development and pathway-focused research. According to supplier technical data, PF573228 molecular formula is C22H20F3N5O3S, and its molecular weight is 491.49. These core descriptors are typically reviewed together with PF573228 chemical structure when scientists confirm compound identity before ordering or screening. :contentReference[oaicite:0]{index=0}
Application of PF573228
PF573228 is widely applied in oncology, cell biology, fibrosis, and extracellular matrix research, especially in workflows centered on focal adhesion kinase signaling. Because FAK is involved in adhesion-dependent survival and migration processes, this molecule is relevant for experiments that examine tumor invasion, cytoskeletal remodeling, endothelial behavior, and signal transmission linked to integrins. PF573228 Pfizer and Pfizer PF573228 are also common search forms used by researchers who want to align internal records with literature references and supplier naming conventions. The combination of recognized activity and clear documentation makes this compound suitable for discovery teams comparing kinase inhibitors across validated experimental systems.
Biological Activity
Available technical references describe pf573228 as a potent and selective inhibitor of focal adhesion kinase with an IC50 of 4 nM. The same sources note 50 - 250-fold selectivity for FAK over other protein kinases and report that the compound blocks serum- and fibronectin-directed migration while decreasing focal adhesion turnover in vitro. These characteristics explain why PF573228 chemical structure and activity data are often reviewed together - researchers are not only checking the identity of the molecule, but also confirming that its biological profile fits migration, phosphorylation, and adhesion-related assays.
Biochemical and Physiological Actions
From a mechanistic perspective, PF-00573228 acts as a non-receptor tyrosine kinase inhibitor directed at FAK. This is important in studies where investigators need to modulate signaling linked to focal adhesions, downstream phosphorylation events, and cellular movement across matrix environments. Cell-based datasets from supplier pages also show inhibition of FAK Tyr397 phosphorylation, effects on migration, changes in apoptosis-related readouts, and altered endothelial responses, supporting its use in broader pathway characterization rather than in a single narrow assay format.
Features and Benefits of PF573228
For product page optimization, the value of PF573228 lies in the balance between technical clarity and research relevance. Key advantages include:
- well-established identifiers, including CAS 869288-64-2, PF573228 molecular formula, and PF573228 chemical structure
- documented FAK-focused activity useful for screening, validation, and mechanism-of-action studies
- strong fit for researchers comparing Pfizer PF573228 with other kinase-directed reference compounds
For laboratories seeking a selective FAK inhibitor with recognized literature support and consistent supplier documentation, pf573228 remains a practical option for structured experimental design and target-based research decisions.
