Decitabine

Decitabine

Decitabine is an analog of cytidine which can be incorporated into DNA, inhibit DNA methyltransferases, and cause hypomethylation of cytosine residues in the absence of any significant mutagenic effects. Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines. It is indicated for the treatment of patients with myelodysplastic syndromes.

2’-deoxy-5-azacytidine | 5-aza-2'-deoxycytidine | 5-aza-2’-deoxycytidine | 5-aza-2′-deoxycytidine | DAC | decitabine