The Hippo signaling pathway is a highly conserved regulatory network, crucial for controlling organ size, tissue regeneration, and cellular proliferation. It functions by integrating extracellular and intracellular signals to modulate gene expression, primarily through the regulation of the YAP/TAZ transcriptional co-activators. The pathway is present in nearly all multicellular organisms, underscoring its essential role in maintaining tissue homeostasis and preventing tumorigenesis. Dysregulation of the Hippo pathway is associated with various cancers, fibrosis, and other pathological conditions, making it a promising therapeutic target in oncology and regenerative medicine.

Library of Hippo signaling pathway ligands comprises 58 small molecules designed to target key components of the pathway. This library includes inhibitors and activators suitable for exploring therapeutic applications in cancer treatment, tissue repair, immune modulation, and metabolic disorders.

Related terms: Hippo, STK3, STK4, LATS2 , LATS1, TEF1, TEF3, TEF4