Neurodegenerative Disease Related Compounds

Library of neurodegenerative disease related compounds includes over 1,500 bioactive compounds targeting 164 proteins from the KEGG database's Neurodegeneration pathways . This diverse selection covers: 

• Protein Misfolding: Dysfunction in the ubiquitin-proteasome and autophagy–lysosome systems leads to the accumulation of misfolded proteins like amyloid-beta and alpha-synuclein.
• Oxidative Stress: Excessive oxidative stress damages cellular components, contributing to neuronal death in diseases like ALS and Huntington's disease.   
• Endoplasmic Reticulum Stress: Accumulation of misfolded proteins in the ER disrupts cellular function and promotes apoptosis, seen in Alzheimer's and Parkinson's diseases.
• Mitochondrial Dysfunction: Impaired mitochondrial function affects ATP production and increases reactive oxygen species, playing a critical role in neurodegenerativeconditions. 
• Disruptions of Axonal Transport: Impaired axonal transport affects the movement of organelles and proteins along axons, leading to neuronal dysfunction and death, observed in ALS and Huntington's disease.
• Neuroinflammation: Chronic inflammation in the nervous system contributes to theprogression of neurodegenerative diseases.

Related terms: Alzheimer's disease, Parkinson's disease, prions, ALS, motor neuron disease, Huntington's disease, spinal muscular atrophy, and spinocerebellar ataxia