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Proteases are enzymes that catalyze proteolysis and can be found in all forms of life, even in viruses. The proteolysis process is realized by cleaving peptide bonds within proteins. Proteases control a variety of physiological processes such as immune response, cell cycle, cell death, wound healing, and food digestion. This fact makes proteases an important group of molecular targets for metabolic disease treatment, as well as the treatment of pathogenic diseases caused by bacteria or viruses.
Protease Inhibitors Library is composed of 774 small ligands. The collection includes compounds with activity against metabolic diseases; inhibitors of ACE2 metalloprotease, which is responsible for SARS-CoV-2 cell entry; ligands with broad-scope antiviral activity; antiprotozoal compounds.
Related terms: methionyl aminopeptidase, dipeptidyl peptidase, cathepsin B, monoacylglycerol lipase, MMP2, MMP8, serine protease, MMP13, angiotensin-converting enzyme
Structure of metalloprotease ACE2, PDBID = 1R42
Saxagliptin, an anti-diabet type 2 EBC-02059
MLN-4760 ACE2 inhibitor EBC-44366
Tenofovir, antiviral EBC-02044
Atovaquone, antiprotozoal EBC-06068
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NoteAll the compounds with solubility below 10 mM are shipped as 2 mM solutions.
Methionyl aminopeptidase 1
16
16
Number of compounds
16
Methionyl aminopeptidase 2
14
14
Number of compounds
14
dipeptidyl peptidase 4
12
12
Number of compounds
12
cathepsin B
11
11
Number of compounds
11
Monoacylglycerol lipase
10
10
Number of compounds
10
MMP2
9
9
Number of compounds
9
MMP8
8
8
Number of compounds
8
serine protease 1
7
7
Number of compounds
7
Caspase 3
7
7
Number of compounds
7
MMP13
7
7
Number of compounds
7
Angiotensin-converting enzyme 2
7
7
Number of compounds
7
calpain 2
6
6
Number of compounds
6
Angiotensin-converting enzyme
6
6
Number of compounds
6
beta-secretase 1
5
5
Number of compounds
5
coagulation factor II, thrombin
5
5
Number of compounds
5
coagulation factor X
5
5
Number of compounds
5
glutaminyl-peptide cyclotransferase
5
5
Number of compounds
5
elastase, neutrophil expressed
5
5
Number of compounds
5
Neutral endopeptidase
5
5
Number of compounds
5
MMP12
4
4
Number of compounds
4
MMP14
4
4
Number of compounds
4
Folate hydrolase (prostate-specific membrane antigen) 1
4
4
Number of compounds
4
MMP9
4
4
Number of compounds
4
cathepsin L
4
4
Number of compounds
4
Caspase 6
3
3
Number of compounds
3
cathepsin S
3
3
Number of compounds
3
legumain
3
3
Number of compounds
3
ubiquitin specific peptidase 14
3
3
Number of compounds
3
ubiquitin specific peptidase 5
3
3
Number of compounds
3
TRH-specific aminopeptidase
3
3
Number of compounds
3
Caspase 8
2
2
Number of compounds
2
Carboxypeptidase A1 (pancreatic)
2
2
Number of compounds
2
CoV 3C-like (main) protease
2
2
Number of compounds
2
MMP3
2
2
Number of compounds
2
ADAM17
2
2
Number of compounds
2
Leukotriene A4 hydrolase
2
2
Number of compounds
2
proteasome 20S subunit beta 5
2
2
Number of compounds
2
Arginyl aminopeptidase
2
2
Number of compounds
2
ADAMTS5
2
2
Number of compounds
2
renin
1
1
Number of compounds
1
Caspase 1
1
1
Number of compounds
1
Caspase 7
1
1
Number of compounds
1
ubiquitin specific peptidase 2
1
1
Number of compounds
1
Aminopeptidase A
1
1
Number of compounds
1
kallikrein related peptidase 3
1
1
Number of compounds
1
kallikrein B1
1
1
Number of compounds
1
plasminogen activator, tissue type
1
1
Number of compounds
1
Carboxypeptidase B1 (tissue)
1
1
Number of compounds
1
ADAM10
1
1
Number of compounds
1
coagulation factor IX
1
1
Number of compounds
1
proprotein convertase subtilisin/kexin type 9
1
1
Number of compounds
1
proteasome 26S subunit, non-ATPase 14
1
1
Number of compounds
1
AKR1C3
1
1
Number of compounds
1
Dipeptidase 1
1
1
Number of compounds
1
chymotrypsin like elastase 1
1
1
Number of compounds
1
proteasome 20S subunit beta 1
1
1
Number of compounds
1
proteasome 20S subunit beta 8
1
1
Number of compounds
1
proteasome 20S subunit beta 9
1
1
Number of compounds
1
proteasome 20S subunit beta 2
1
1
Number of compounds
1
kallikrein related peptidase 7
1
1
Number of compounds
1
Endothelin-converting enzyme 1
1
1
Number of compounds
1
cathepsin D
1
1
Number of compounds
1
ubiquitin C-terminal hydrolase L1
1
1
Number of compounds
1
cathepsin H
1
1
Number of compounds
1
cathepsin K
1
1
Number of compounds
1
Dipeptidyl-peptidase 7
1
1
Number of compounds
1
dipeptidyl peptidase 8
1
1
Number of compounds
1
dipeptidyl peptidase 9
1
1
Number of compounds
1
Aminopeptidase N
1
1
Number of compounds
1
Leucine aminopeptidase 3
1
1
Number of compounds
1
complement factor B
1
1
Number of compounds
1
ADAMTS4
1
1
Number of compounds
1
ubiquitin C-terminal hydrolase L3
1
1
Number of compounds
1
ubiquitin specific peptidase 1
1
1
Number of compounds
1
EBCL-0010