Effective neural communication is essential for all aspects of the nervous system's operation, spanning from its role in development and throughout the entire lifespan, including health and disease. Investigation of neuronal signaling pathways is essential for advancing our understanding of brain function, identifying the mechanisms underlying neurological and psychiatric disorders, and developing effective treatments and therapies.

Neurotransmitter receptors are mainly divided into ionotropic and metabotropic. Ionotropic indicates that ions can pass through the receptor, whereas metabotropic indicates that a second messenger inside the cell passes the message. Several kinds of metabotropic receptors, such as G protein-coupled receptors (including 5-HT receptor, histamine receptor, opioid receptor, etc.) as well as various ionotropic receptors (ligand-gated ion channels) are important therapeutic targets in neuronal signaling.Notch signaling also impacts to central nervous system including regulating neural stem cell proliferation, survival, self-renewal, and differentiation.

Neuronal Signaling Related Ligands Library contains 2619 small ligands, some representative molecules are given below: Acetylcholine (associated with Alzheimer's disease and myasthenia gravis), Gabapentin (epilepsy and seizures), Dopamine (Parkinson's disease) and Serotonin (depression).

Related terms: GPCR, ligand-gated IC, voltage-gated IC, catecholamine turnover, acetylcholine turnover, SLC6 neurotransmitter transporter family, GABA, CAMK, NAK