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Ion channels are a large group of membrane proteins, also called the passive-transport systems, characterized by a very high ion-transport rate. Ion channels are represented in almost every type of living cell, as well as in cell organelles. They play a principal role in cell homeostasis and can be considered therapeutic targets for CNS disorders, pain control, inflammatory processes, cardiovascular diseases, and some pathogenic diseases. While many efficient ion channel-targeting drugs exist, these molecules remain a highly unexplored group of proteins.
Ion Channel Ligands Library is composed of 1029 small molecules. The library covers ligands suitable for application in many medicinal areas: cardiovascular regulation, neuroscience, pain suppression, and immune response regulation.
Related terms: CFTR, L-type calcium channel, Kv11.1, 5-HT3A, GABAA receptor, TRPA1, GluN2D, NMDA receptor, TRPV1, nicotinic acetylcholine receptor
Action of ion channel(Created by BioRender.com)
Amiodarone, antiarrythmic EBC-07659
Ro4938581, nootripic EBC-14756
Vecuronium bromide, anesthetic EBC-11164
Loratadine, antihistamine EBC-11203
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NoteAll the compounds with solubility below 10 mM are shipped as 2 mM solutions.
CFTR
36
36
Number of compounds
36
L-type calcium channel
33
33
Number of compounds
33
Kv11.1
31
31
Number of compounds
31
5-HT3A
28
28
Number of compounds
28
GABAA receptor α1 subunit
27
27
Number of compounds
27
GABAA receptor β2 subunit
27
27
Number of compounds
27
GABAA receptor δ subunit
26
26
Number of compounds
26
TRPA1
25
25
Number of compounds
25
GluN2D
21
21
Number of compounds
21
NMDA receptor
21
21
Number of compounds
21
TRPV1
18
18
Number of compounds
18
Cav1.1
17
17
Number of compounds
17
nicotinic acetylcholine receptor β2 subunit
17
17
Number of compounds
17
GABAA receptor
17
17
Number of compounds
17
Cav1.2
16
16
Number of compounds
16
nicotinic acetylcholine receptor α-like 1
16
16
Number of compounds
16
nicotinic acetylcholine receptor α4 subunit
16
16
Number of compounds
16
nicotinic acetylcholine receptor α7 subunit
15
15
Number of compounds
15
nicotinic acetylcholine receptor γ1 subunit
15
15
Number of compounds
15
nicotinic acetylcholine receptor δ1 subunit
15
15
Number of compounds
15
nicotinic acetylcholine receptor β-like 1
15
15
Number of compounds
15
glycine receptor α1 subunit
15
15
Number of compounds
15
P2X7
14
14
Number of compounds
14
GluN2B
14
14
Number of compounds
14
GABAA receptor γ2 subunit
14
14
Number of compounds
14
nicotinic acetylcholine receptor
14
14
Number of compounds
14
GABAA receptor β3 subunit
12
12
Number of compounds
12
Voltage-gated sodium channel
11
11
Number of compounds
11
GluN2C
10
10
Number of compounds
10
Nav1.7
10
10
Number of compounds
10
GABAA receptor α2 subunit
10
10
Number of compounds
10
GABAA receptor α3 subunit
10
10
Number of compounds
10
GABAA receptor γ2s subunit
10
10
Number of compounds
10
TRPM7
9
9
Number of compounds
9
Nav1.2
9
9
Number of compounds
9
GABAA receptor α6 subunit
9
9
Number of compounds
9
GABAA receptor β1 subunit
9
9
Number of compounds
9
Nav1.5
9
9
Number of compounds
9
Kv9.1
8
8
Number of compounds
8
Nav1.1
8
8
Number of compounds
8
GABAA receptor α4 subunit
8
8
Number of compounds
8
GABAA receptor α5 subunit
8
8
Number of compounds
8
nicotinic acetylcholine receptor β4 subunit
7
7
Number of compounds
7
Cav2.2
7
7
Number of compounds
7
Nav1.8
7
7
Number of compounds
7
Navβ1
7
7
Number of compounds
7
KCa3.1
6
6
Number of compounds
6
Kv7.1
6
6
Number of compounds
6
KNa1.1
6
6
Number of compounds
6
GluN1a
6
6
Number of compounds
6
Kir
6
6
Number of compounds
6
Nav1.9
6
6
Number of compounds
6
nicotinic acetylcholine receptor α3 subunit
6
6
Number of compounds
6
K2P3.1
6
6
Number of compounds
6
K2P18.1
5
5
Number of compounds
5
Cav3.1
5
5
Number of compounds
5
Kir3.1
5
5
Number of compounds
5
5-HT3B
5
5
Number of compounds
5
Kv4.3
5
5
Number of compounds
5
nicotinic acetylcholine receptor α2 subunit
5
5
Number of compounds
5
nicotinic acetylcholine receptor β3 subunit
5
5
Number of compounds
5
Cav1.3
4
4
Number of compounds
4
Kir3.2
4
4
Number of compounds
4
GABAA receptor ρ1 subunit
4
4
Number of compounds
4
Kv7.2
4
4
Number of compounds
4
Kv7.3
4
4
Number of compounds
4
GABAA receptor γ2L subunit
4
4
Number of compounds
4
Cav2.1
4
4
Number of compounds
4
Nav1.4
4
4
Number of compounds
4
KCa2.2
4
4
Number of compounds
4
nicotinic acetylcholine receptor α5 subunit
4
4
Number of compounds
4
nicotinic acetylcholine receptor α-like 2
4
4
Number of compounds
4
Cav3.2
3
3
Number of compounds
3
TRPM5
3
3
Number of compounds
3
GluK1
3
3
Number of compounds
3
nicotinic acetylcholine receptor α9 subunit
3
3
Number of compounds
3
Nav1.6
3
3
Number of compounds
3
Kir3.4
3
3
Number of compounds
3
P2X4
3
3
Number of compounds
3
TRPM8
3
3
Number of compounds
3
Kir2.1
3
3
Number of compounds
3
Kir4.1
3
3
Number of compounds
3
KCa
3
3
Number of compounds
3
KCa2
3
3
Number of compounds
3
TRPC6
3
3
Number of compounds
3
Kir6.2
3
3
Number of compounds
3
nicotinic acetylcholine receptor β-like 2
3
3
Number of compounds
3
nicotinic acetylcholine receptor α1 subunit
3
3
Number of compounds
3
nicotinic acetylcholine receptor β1 subunit
3
3
Number of compounds
3
nicotinic acetylcholine receptor δ subunit
3
3
Number of compounds
3
Kv3.1
3
3
Number of compounds
3
nicotinic acetylcholine receptor α-type acr-16
3
3
Number of compounds
3
Kv1.3
2
2
Number of compounds
2
GluA2 flip
2
2
Number of compounds
2
GluA2 flop
2
2
Number of compounds
2
nicotinic acetylcholine receptor α10 subunit
2
2
Number of compounds
2
KCa1.1
2
2
Number of compounds
2
P2X2
2
2
Number of compounds
2
P2X1
2
2
Number of compounds
2
GABAA receptor γ1 subunit
2
2
Number of compounds
2
GABAA receptor ρ2 subunit
2
2
Number of compounds
2
GABAA receptor ρ3 subunit
2
2
Number of compounds
2
GABAA receptor σ subunit
2
2
Number of compounds
2
GABAA receptor β subunit
2
2
Number of compounds
2
GABAA receptor α subunit
2
2
Number of compounds
2
N-type calcium channel
2
2
Number of compounds
2
Cav1.2 subunit α2δ
2
2
Number of compounds
2
TRPV3
2
2
Number of compounds
2
Kv1.5
2
2
Number of compounds
2
GluN3A
2
2
Number of compounds
2
TRPV4
2
2
Number of compounds
2
5-HT3AB
2
2
Number of compounds
2
KCa2.1
2
2
Number of compounds
2
KCa2.3
2
2
Number of compounds
2
TRPC5
2
2
Number of compounds
2
nicotinic acetylcholine receptor α6 subunit
2
2
Number of compounds
2
nicotinic acetylcholine receptor γ subunit
2
2
Number of compounds
2
nicotinic acetylcholine receptor α16 subunit
2
2
Number of compounds
2
nicotinic acetylcholine receptor δ
2
2
Number of compounds
2
nicotinic acetylcholine receptor γ
2
2
Number of compounds
2
Kv4.2
2
2
Number of compounds
2
K2P9.1
2
2
Number of compounds
2
Kv7.4
2
2
Number of compounds
2
TRPV2
2
2
Number of compounds
2
GluK2
2
2
Number of compounds
2
Kir2.3
1
1
Number of compounds
1
5-HT3
1
1
Number of compounds
1
TRPM2
1
1
Number of compounds
1
KCaβ1
1
1
Number of compounds
1
P2X3
1
1
Number of compounds
1
P2X2/3
1
1
Number of compounds
1
GluN3
1
1
Number of compounds
1
TRPML3
1
1
Number of compounds
1
TRPML1
1
1
Number of compounds
1
RyR1
1
1
Number of compounds
1
GABAA receptor θ subunit
1
1
Number of compounds
1
GABAA receptor π subunit
1
1
Number of compounds
1
GABAA receptor α4β3δ subunit
1
1
Number of compounds
1
GABAA receptor exp-1
1
1
Number of compounds
1
GABAA receptor α5 subunit (F53W)
1
1
Number of compounds
1
GABAA receptor α5 subunit (F53W;L222W)
1
1
Number of compounds
1
GABAA receptor α5 subunit (L222W)
1
1
Number of compounds
1
glycine receptor β subunit
1
1
Number of compounds
1
GluN1-1a
1
1
Number of compounds
1
GluN1-4a
1
1
Number of compounds
1
GluN2B (D668N)
1
1
Number of compounds
1
GluN1 (E662K)
1
1
Number of compounds
1
GluN2B (E807K)
1
1
Number of compounds
1
K2P2.1
1
1
Number of compounds
1
TRPC4
1
1
Number of compounds
1
TRPM3
1
1
Number of compounds
1
RyR2
1
1
Number of compounds
1
nicotinic acetylcholine receptor ε subunit
1
1
Number of compounds
1
AQP4
1
1
Number of compounds
1
nicotinic acetylcholine receptor α4β2 subunit
1
1
Number of compounds
1
nicotinic acetylcholine receptor α-like 4
1
1
Number of compounds
1
Nav1.3
1
1
Number of compounds
1
CFTR (G551D)
1
1
Number of compounds
1
CFTR (G551S)
1
1
Number of compounds
1
CFTR (delF508)
1
1
Number of compounds
1
CFTR (G970R)
1
1
Number of compounds
1
CFTR (G1244E)
1
1
Number of compounds
1
CFTR (S1255P)
1
1
Number of compounds
1
CFTR (G1349D)
1
1
Number of compounds
1
TRPV1 (T551V)
1
1
Number of compounds
1
ClC-1
1
1
Number of compounds
1
nicotinic acetylcholine receptor (α1)2β1δ5 subunit
1
1
Number of compounds
1
Kir1.1
1
1
Number of compounds
1
Kir7.1
1
1
Number of compounds
1
GluN3B
1
1
Number of compounds
1
GluN2A (M817V)
1
1
Number of compounds
1
GluN2A (P552R)
1
1
Number of compounds
1
TRP channel
1
1
Number of compounds
1
Kv10.1
1
1
Number of compounds
1
TRPC3
1
1
Number of compounds
1
TRPC7
1
1
Number of compounds
1
EBCL-0018