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The Traditional Chinese Medicine Active Compound Library is a collection of bioactive compounds, bridging ancient medicinal wisdom with modern scientific exploration. This extensive library provides access to a wide array of compounds that influence critical biological pathways, with potential applications in areas such as inflammation, oxidative stress, metabolic regulation, neuroprotection, and more.
Among the well-known compounds are:
- Curcumin, recognized for its potent anti-inflammatory and antioxidant properties. It modulates key pathways like NF-κB and MAPK, contributing to the reduction of inflammation and oxidative damage. It is also potentially active in preventing neurodegenerative diseases like Alzheimer’s.
- Resveratrol is a widely researched antioxidant, which regulates pathways such as SIRT1 and AMPK. Its broad therapeutic potential includes aging, cardioprotection, cancer prevention, and metabolic regulation.
- Quercetin, a flavonoid found in many fruits and vegetables, is known for its ability to regulate inflammation by inhibiting enzymes like COX-2 and activating the Nrf2 antioxidant pathway. It has been studied for its protective effects against oxidative stress and potential cancer-preventive properties.
- Theobromine, a compound from cacao, acts as a mild stimulant with cardiovascular benefits. It influences adenosine receptors and serves as a vasodilator, enhancing blood flow, and is of great interest for its potential in mood regulation and heart health.
The TCM Active Compound Library integrates solubility, pathway targeting, and biological activity insights, making it invaluable resource for researchers exploring the pharmacological potential of TCM-derived compounds in modern medicine.
Related terms: chinese medicine, alternative medicine, natural products, inflammation, antioxidants, adenosine receptors, NF-κB, COX-2, MAP kinase
Bergenin is a glycoside and a major constituent of Peltophorum plants and has diverse biological activities.
(-)-Verbenone is a natural terpene in leaves of the tree, Suregada zanzibariensis Verdc.
Aloperine is an alkaloid found in the roots of S. flavescens with diverse biological activities.
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NoteAll the compounds with solubility below 10 mM are shipped as 2 mM solutions.
Others
1166
1166
Number of compounds
1166
Antibacterial
188
188
Number of compounds
188
Oxidoreductases
100
100
Number of compounds
100
Antiviral
98
98
Number of compounds
98
Acetylcholine turnover
76
76
Number of compounds
76
Nitric oxide synthases
48
48
Number of compounds
48
Antifungal
43
43
Number of compounds
43
Transient Receptor Potential channels (TRP)
41
41
Number of compounds
41
Carbonic anhydrases
39
39
Number of compounds
39
p38 subfamily
35
35
Number of compounds
35
Nicotinic acetylcholine receptors (nACh)
33
33
Number of compounds
33
Antiparasitic
31
31
Number of compounds
31
Voltage-gated calcium channels (CaV)
31
31
Number of compounds
31
CYP2 family: drug metabolising subset
29
29
Number of compounds
29
Glycosidases
29
29
Number of compounds
29
GABAA receptors
28
28
Number of compounds
28
CYP1 family
27
27
Number of compounds
27
1C. Peroxisome proliferator-activated receptors
21
21
Number of compounds
21
Type XIII RTKs: Ephrin receptor family
21
21
Number of compounds
21
3B. Estrogen-related receptors
20
20
Number of compounds
20
3C. 3-Ketosteroid receptors
19
19
Number of compounds
19
S1: Chymotrypsin
19
19
Number of compounds
19
5-Hydroxytryptamine receptors
19
19
Number of compounds
19
AMPK subfamily
19
19
Number of compounds
19
Hydrolases
18
18
Number of compounds
18
Lipoxygenases
18
18
Number of compounds
18
"Akt (Protein kinase B, PKB) family"
18
18
Number of compounds
18
3A. Estrogen receptors
16
16
Number of compounds
16
ABCB subfamily
15
15
Number of compounds
15
Histone deacetylases (HDACs)
14
14
Number of compounds
14
Catecholamine turnover
14
14
Number of compounds
14
Alpha subfamily
14
14
Number of compounds
14
JNK subfamily
13
13
Number of compounds
13
Adrenoceptors
13
13
Number of compounds
13
Ionotropic glutamate receptors
12
12
Number of compounds
12
"Calcium- and sodium-activated potassium channels (KCa, KNa)"
12
12
Number of compounds
12
"Phosphatidylinositol-4,5-bisphosphate 3-kinase family"
12
12
Number of compounds
12
P4 P-type ATPases: Phospholipid-transporting ATPases
12
12
Number of compounds
12
Free fatty acid receptors
12
12
Number of compounds
12
Class A Orphans
11
11
Number of compounds
11
Voltage-gated potassium channels (Kv)
10
10
Number of compounds
10
Receptor tyrosine phosphatase (RTP) family
8
8
Number of compounds
8
M2: Angiotensin-converting enzymes (ACE and ACE2)
8
8
Number of compounds
8
Aryl hydrocarbon receptor
7
7
Number of compounds
7
Opioid receptors
7
7
Number of compounds
7
S9: Prolyl oligopeptidase
7
7
Number of compounds
7
ABCG subfamily
7
7
Number of compounds
7
Dopamine receptors
7
7
Number of compounds
7
M28: Aminopeptidase Y
7
7
Number of compounds
7
Voltage-gated sodium channels (NaV)
7
7
Number of compounds
7
SLC49 family of FLVCR-related heme transporters
7
7
Number of compounds
7
Succinate receptor
6
6
Number of compounds
6
Cannabinoid receptors
6
6
Number of compounds
6
Organic anion transporters (OATs)
6
6
Number of compounds
6
"CYP11, CYP17, CYP19, CYP20 and CYP21 families"
6
6
Number of compounds
6
Histamine receptors
6
6
Number of compounds
6
Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family
6
6
Number of compounds
6
Glycine receptors
6
6
Number of compounds
6
Acyltransferases
6
6
Number of compounds
6
E3 ubiquitin ligase components
5
5
Number of compounds
5
Adenosine receptors
5
5
Number of compounds
5
Metabotropic glutamate receptors
5
5
Number of compounds
5
A1: Pepsin
5
5
Number of compounds
5
Aurora kinase (Aur) family
5
5
Number of compounds
5
ABCC subfamily
5
5
Number of compounds
5
M10: Matrix metallopeptidase
5
5
Number of compounds
5
Bile acid receptor
5
5
Number of compounds
5
FRAP subfamily
5
5
Number of compounds
5
SLC35 family of nucleotide sugar transporters
5
5
Number of compounds
5
Prostaglandin synthases
5
5
Number of compounds
5
Dioxygenases
5
5
Number of compounds
5
UDP glucuronosyltransferases (UGT)
5
5
Number of compounds
5
Poly ADP-ribose polymerases
5
5
Number of compounds
5
SLC7 family
5
5
Number of compounds
5
GSK subfamily
5
5
Number of compounds
5
H+/K+-ATPases
5
5
Number of compounds
5
Glycine transporter subfamily
4
4
Number of compounds
4
Hydroxycarboxylic acid receptors
4
4
Number of compounds
4
GABA transporter subfamily
4
4
Number of compounds
4
Organic cation transporters (OCT)
4
4
Number of compounds
4
Alanine/serine/cysteine transporter subfamily
4
4
Number of compounds
4
"Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs)"
4
4
Number of compounds
4
Fatty acid-binding proteins
4
4
Number of compounds
4
Type I RTKs: ErbB (epidermal growth factor) receptor family
4
4
Number of compounds
4
Calcium-sensing receptor
4
4
Number of compounds
4
Arginase
4
4
Number of compounds
4
Janus kinase (JakA) family
4
4
Number of compounds
4
Adenosine turnover
4
4
Number of compounds
4
Fak family
4
4
Number of compounds
4
Protein kinase A (PKA) family
4
4
Number of compounds
4
DNA topoisomerases
3
3
Number of compounds
3
Class Frizzled GPCRs
3
3
Number of compounds
3
Taste 1 receptors
3
3
Number of compounds
3
2-Acylglycerol ester turnover
3
3
Number of compounds
3
SLCO family of organic anion transporting polypeptides
3
3
Number of compounds
3
Tubulins
3
3
Number of compounds
3
Heat shock proteins
3
3
Number of compounds
3
Ryanodine receptors (RyR)
3
3
Number of compounds
3
CYP3 family
3
3
Number of compounds
3
Class C Orphans
3
3
Number of compounds
3
C2: Calpain
3
3
Number of compounds
3
"CYP39, CYP46 and CYP51 families"
3
3
Number of compounds
3
C1: Papain
3
3
Number of compounds
3
1I. Vitamin D receptor-like receptors
3
3
Number of compounds
3
Basic leucine zipper domain TFs
3
3
Number of compounds
3
Histone acetyltransferases (HATs)
3
3
Number of compounds
3
CFTR
3
3
Number of compounds
3
ClC family
3
3
Number of compounds
3
Lanosterol biosynthesis pathway
3
3
Number of compounds
3
Type II RTKs: Insulin receptor family
3
3
Number of compounds
3
Integrins
3
3
Number of compounds
3
Two-pore domain potassium channels (K2P)
2
2
Number of compounds
2
1-phosphatidylinositol 4-kinase family
2
2
Number of compounds
2
"Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family"
2
2
Number of compounds
2
NOD-like receptor family
2
2
Number of compounds
2
Melatonin receptors
2
2
Number of compounds
2
Atypical SLC22B subfamily
2
2
Number of compounds
2
Polo-like kinase (PLK) family
2
2
Number of compounds
2
Decarboxylases
2
2
Number of compounds
2
Toll-like receptor family
2
2
Number of compounds
2
PIM family
2
2
Number of compounds
2
Bromodomain kinase (BRDK) family
2
2
Number of compounds
2
Nucleotide turnover
2
2
Number of compounds
2
Histone demethylases
2
2
Number of compounds
2
Monoamine transporter subfamily
2
2
Number of compounds
2
SLC3 family
2
2
Number of compounds
2
Tec family
2
2
Number of compounds
2
Trace amine receptor
2
2
Number of compounds
2
M1: Aminopeptidase N
2
2
Number of compounds
2
Platelet-activating factor receptor
2
2
Number of compounds
2
IRE family
2
2
Number of compounds
2
"GPR18, GPR55 and GPR119"
2
2
Number of compounds
2
1H. Liver X receptor-like receptors
2
2
Number of compounds
2
Blood coagulation components
2
2
Number of compounds
2
Inwardly rectifying potassium channels (KIR)
2
2
Number of compounds
2
p70 subfamily
2
2
Number of compounds
2
Lipid phosphate phosphatases
2
2
Number of compounds
2
SGK family
1
1
Number of compounds
1
Adiponectin receptors
1
1
Number of compounds
1
Protein arginine N-methyltransferases
1
1
Number of compounds
1
MAPKAPK subfamily
1
1
Number of compounds
1
Pyrimidine salvage
1
1
Number of compounds
1
Motilin receptor
1
1
Number of compounds
1
SLC29 family
1
1
Number of compounds
1
GABAB receptors
1
1
Number of compounds
1
NADPH oxidases
1
1
Number of compounds
1
Eta subfamily
1
1
Number of compounds
1
2B. Retinoid X receptors
1
1
Number of compounds
1
SLC47 family of multidrug and toxin extrusion transporters
1
1
Number of compounds
1
STAT transcription factors
1
1
Number of compounds
1
Type I receptor serine/threonine kinases
1
1
Number of compounds
1
C14: Caspase
1
1
Number of compounds
1
Glucagon receptor family
1
1
Number of compounds
1
M12: Astacin/Adamalysin
1
1
Number of compounds
1
Cyclic GMP-AMP synthase
1
1
Number of compounds
1
Class II transporters
1
1
Number of compounds
1
Csk family
1
1
Number of compounds
1
SLC16 family of monocarboxylate transporters
1
1
Number of compounds
1
Non-enzymatic BRD containing proteins
1
1
Number of compounds
1
Thyroid hormone turnover
1
1
Number of compounds
1
Acetylcholine receptors (muscarinic)
1
1
Number of compounds
1
SLC15 family of peptide transporters
1
1
Number of compounds
1
M14: Carboxypeptidase A
1
1
Number of compounds
1
Haem oxygenase
1
1
Number of compounds
1
Src family
1
1
Number of compounds
1
ATPases
1
1
Number of compounds
1
PDK1 family
1
1
Number of compounds
1
"Sodium iodide symporter, sodium-dependent multivitamin transporter and sodium-coupled monocarboxylate transporters"
1
1
Number of compounds
1
Casein kinase 1 (CK1) family
1
1
Number of compounds
1
Orphan or poorly characterized SLC22 family members
1
1
Number of compounds
1
Adenylyl cyclases (ACs)
1
1
Number of compounds
1
Leukotriene receptors
1
1
Number of compounds
1
Glutaminases
1
1
Number of compounds
1
C44: Phosphoribosyl pyrophosphate amidotransferase
1
1
Number of compounds
1
B-cell lymphoma 2 (Bcl-2) protein family
1
1
Number of compounds
1
N-Acylethanolamine turnover
1
1
Number of compounds
1
Cholecystokinin receptors
1
1
Number of compounds
1
Phospholipase A2
1
1
Number of compounds
1
GABA turnover
1
1
Number of compounds
1
Purine-nucleoside phosphorylase
1
1
Number of compounds
1
SLC10 family of sodium-bile acid co-transporters
1
1
Number of compounds
1
Chemokine receptors
1
1
Number of compounds
1
Type X RTKs: HGF (hepatocyte growth factor) receptor family
1
1
Number of compounds
1
Angiotensin receptors
1
1
Number of compounds
1
1A. Thyroid hormone receptors
1
1
Number of compounds
1
CYP4 family
1
1
Number of compounds
1
RSK subfamily
1
1
Number of compounds
1
Glutathione transferases
1
1
Number of compounds
1
NKF2 family
1
1
Number of compounds
1
P2X receptors
1
1
Number of compounds
1
Isocitrate dehydrogenases
1
1
Number of compounds
1
PDHK family
1
1
Number of compounds
1
SLC18 family of vesicular amine transporters
1
1
Number of compounds
1
Vasopressin and oxytocin receptors
1
1
Number of compounds
1
Interferon receptor family
1
1
Number of compounds
1
Glutamate transporter subfamily
1
1
Number of compounds
1
Inhibitors of apoptosis (IAP) protein family
1
1
Number of compounds
1
Histone methyltransferases (HMTs)
1
1
Number of compounds
1
Other pattern recognition receptors
1
1
Number of compounds
1
Interleukin-1 receptor-associated kinase (IRAK) family
1
1
Number of compounds
1
EBCL-0044