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Angiogenesis is the essential physiological process of the formation of new blood vessels from existing ones, formed earlier at the stage of vasculogenesis. It is a crucial process for the growth and development of the human body, as well as for wound healing by the formation of granulation tissue. Disorders in the angiogenesis-related signaling pathways lead to cancer or cardiovascular diseases. These diseases can be controlled by exogenous angiogenesis activators (cardiovascular) or inhibitors (cancer). Some key activators of angiogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, TGF-β, etc. The angiogenesis inhibitors are angiostatin, endostatin, interferon, platelet factor 4, etc.
Angiogenesis Related Ligands Library consists of 677 small ligands, some representative molecules are given below: TSC359, FLT3 inhibitor; ML106, DYRK1A inhibitor; DB04760, Collagenase 3 inhibitor; Fedratinib, Cyclin-G-associated kinase inhibitor.
Related terms: COX-1 , COX-2, epidermal growth factor, fms related receptor tyrosine kinase, platelet derived growth factor, fibroblast growth factor, AT1 receptor, MMP8
Representation of the connection between angiogenesis and cancer tumor growth (Created By BioRender.com)
TCS 359, FLT3 inhibitor EBC-00624
ML106, DYRK1A inhibitor EBC-00707
DB04760, Collagenase 3 inhibitor EBC-47495
Fedratinib, Cyclin-G-associated kinase inhibitor EBC-17140
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NoteAll the compounds with solubility below 10 mM are shipped as 2 mM solutions.
COX-2
32
32
Number of compounds
32
epidermal growth factor receptor
29
29
Number of compounds
29
COX-1
24
24
Number of compounds
24
fms related receptor tyrosine kinase 3
21
21
Number of compounds
21
kinase insert domain receptor
16
16
Number of compounds
16
platelet derived growth factor receptor alpha
15
15
Number of compounds
15
platelet derived growth factor receptor beta
14
14
Number of compounds
14
colony stimulating factor 1 receptor
12
12
Number of compounds
12
fibroblast growth factor receptor 1
12
12
Number of compounds
12
AT1 receptor
10
10
Number of compounds
10
MMP8
8
8
Number of compounds
8
erb-b2 receptor tyrosine kinase 2
8
8
Number of compounds
8
MMP13
7
7
Number of compounds
7
MMP2
7
7
Number of compounds
7
fibroblast growth factor receptor 2
6
6
Number of compounds
6
fms related receptor tyrosine kinase 1
6
6
Number of compounds
6
CXCR4
6
6
Number of compounds
6
fms related receptor tyrosine kinase 4
5
5
Number of compounds
5
erb-b2 receptor tyrosine kinase 4
5
5
Number of compounds
5
MMP12
4
4
Number of compounds
4
3-phosphoinositide dependent protein kinase 1
4
4
Number of compounds
4
MMP14
4
4
Number of compounds
4
EPH receptor A2
4
4
Number of compounds
4
KCa3.1
4
4
Number of compounds
4
fibroblast growth factor receptor 3
3
3
Number of compounds
3
EP2 receptor
3
3
Number of compounds
3
MMP9
3
3
Number of compounds
3
SST1 receptor
3
3
Number of compounds
3
SST4 receptor
3
3
Number of compounds
3
EP4 receptor
3
3
Number of compounds
3
EPH receptor B4
2
2
Number of compounds
2
MMP3
2
2
Number of compounds
2
SST3 receptor
2
2
Number of compounds
2
PAF receptor
2
2
Number of compounds
2
TEK receptor tyrosine kinase
2
2
Number of compounds
2
Liver X receptor-α
1
1
Number of compounds
1
CXCR2
1
1
Number of compounds
1
fibroblast growth factor receptor 4
1
1
Number of compounds
1
EPH receptor B1
1
1
Number of compounds
1
EPH receptor A3
1
1
Number of compounds
1
EPH receptor A7
1
1
Number of compounds
1
EBCL-0009