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The chemical signals outside of the cell to the cell nucleus are transferred by JAK-STAT signaling pathways. These pathways are involved in cell division and death, processes of the immune response, etc. Initially, the dimerization of the extracellular domains of receptor Janus kinase(JAK) brings together the intracellular domains of protein induced by ligand binding(cytokine, for example). The JAKs phosphorylate each other, resulting in the activation of the kinases. The activated JAKs can phosphorylate a regulator of gene expression called STAT(Signal Transducer and Activator of Transcription). Activated STAT moves to the nucleus to regulate gene expression. Any deviations during JAK-STAT signaling pathways may lead to cancer, serious skin diseases, or immune system disorders. Thus, investigation in this area is one of the valuable targets for drug discovery.
JAK-STAT Signaling Ligands Library contains 383 small ligands, some representative molecules are given below: Pazopanib, VEGFR receptor inhibitor; LY294002, TPK inhibitor; PF06700841, JAK1 inhibitor; SH-4-54, STAT3 inhibitor.
Related terms: epidermal growth factor, Janus kinase, platelet derived growth factor, Pim-1 proto-oncogene, serine/threonine kinase, colony stimulating factor, interleukin
JAK-STAT signaling pathway(Created by BioRender.com)
Pazopanib, VEGF receptor inhibitor EBC-12617
LY294002, Tyrosine-protein kinases inhibitor EBC-11275
PF-06700841, JAK1 inhibitor EBC-00709
SH-4-54, STAT3 inhibitor EBC-13762
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NoteAll the compounds with solubility below 10 mM are shipped as 2 mM solutions.
epidermal growth factor receptor
80
80
Number of compounds
80
Janus kinase 2
48
48
Number of compounds
48
platelet derived growth factor receptor beta
39
39
Number of compounds
39
Janus kinase 3
38
38
Number of compounds
38
Pim-1 proto-oncogene, serine/threonine kinase
37
37
Number of compounds
37
platelet derived growth factor receptor alpha
36
36
Number of compounds
36
colony stimulating factor 1 receptor
34
34
Number of compounds
34
interleukin 1 receptor associated kinase 4
32
32
Number of compounds
32
tyrosine kinase 2
31
31
Number of compounds
31
AKT serine/threonine kinase 1
30
30
Number of compounds
30
interleukin 1 receptor associated kinase 1
28
28
Number of compounds
28
B-Raf proto-oncogene, serine/threonine kinase
27
27
Number of compounds
27
Janus kinase 1
25
25
Number of compounds
25
signal transducer and activator of transcription 3
20
20
Number of compounds
20
Pim-3 proto-oncogene, serine/threonine kinase
19
19
Number of compounds
19
AKT serine/threonine kinase 2
18
18
Number of compounds
18
Raf-1 proto-oncogene, serine/threonine kinase
18
18
Number of compounds
18
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
14
14
Number of compounds
14
AKT serine/threonine kinase 3
12
12
Number of compounds
12
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
9
9
Number of compounds
9
E1A binding protein p300
9
9
Number of compounds
9
phosphoinositide-3-kinase regulatory subunit 1
8
8
Number of compounds
8
interleukin 1 receptor associated kinase 3
8
8
Number of compounds
8
Interleukin-2 receptor
4
4
Number of compounds
4
Interleukin 21 receptor
4
4
Number of compounds
4
Thrombopoietin receptor
4
4
Number of compounds
4
Interferon-γ receptor
4
4
Number of compounds
4
phosphoinositide-3-kinase regulatory subunit 2
3
3
Number of compounds
3
Interleukin-4 receptor subunit α
3
3
Number of compounds
3
Interleukin-13 receptor subunit α1
3
3
Number of compounds
3
Interleukin 23 receptor
3
3
Number of compounds
3
Eythropoietin receptor
3
3
Number of compounds
3
Granulocyte colony-stimulating factor receptor
3
3
Number of compounds
3
Interleukin-10 receptor
3
3
Number of compounds
3
Interleukin-12 receptor
3
3
Number of compounds
3
Interleukin-7 receptor
3
3
Number of compounds
3
Interleukin-15 receptor
3
3
Number of compounds
3
Interleukin-6 receptor
3
3
Number of compounds
3
Interleukin-27 receptor
3
3
Number of compounds
3
Interleukin-3 receptor
2
2
Number of compounds
2
Granulocyte macrophage colony-stimulating factor receptor
2
2
Number of compounds
2
CREB binding protein
2
2
Number of compounds
2
A-Raf proto-oncogene, serine/threonine kinase
1
1
Number of compounds
1
RAS guanyl releasing protein 1
1
1
Number of compounds
1
phosphoinositide-3-kinase regulatory subunit 3
1
1
Number of compounds
1
signal transducer and activator of transcription 6
1
1
Number of compounds
1
Bcl-2-like 1
1
1
Number of compounds
1
mechanistic target of rapamycin kinase
1
1
Number of compounds
1
Interferon γ receptor 1
1
1
Number of compounds
1
protein tyrosine phosphatase non-receptor type 22
1
1
Number of compounds
1
EBCL-0019