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Cytokines are signal molecules that bind to the receptor proteins on the surface of immune system cells, provoking an immunological response. They include chemokines, interferons, interleukins, lymphokines, and tumor necrosis factors. Growth factors are important molecules for the regulation of a variety of cellular processes. These compounds stimulate cell proliferation, regeneration, and cell differentiation. Together cytokines and growth factors are weighty parts of the immune system's responses to infection, inflammation, trauma, sepsis, cancer and reproduction, becoming prominent pharmaceutical targets.
Growth Factors and Cytokines Ligands Library contains 411 small ligands, some representative molecules are given below: Ceritinib, ALK tyrosine kinase receptor inhibitor; Lucitanib, VEGFR and FGFR inhibitor; MSX-127, CXCR4 antagonist; Eltrombopag, Thrombopoietin receptor agonist.
Related terms: epidermal growth factor, fms related receptor tyrosine kinase, kinase insert domain receptor, fibroblast growth factor, platelet derived growth factor
Biological action of cytokines on TPO receptor(Created by BioRender.com)
Ceritinib, ALK tyrosine kinase receptor inhibitor EBC-12909
Lucitanib, VEGFR and FGFR inhibitor EBC-50063
MSX-127, CXCR4 antagonist EBC-08714
Eltrombopag, Thrombopoietin receptor agonist EBC-13607
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NoteAll the compounds with solubility below 10 mM are shipped as 2 mM solutions.
epidermal growth factor receptor
43
43
Number of compounds
43
fms related receptor tyrosine kinase 3
33
33
Number of compounds
33
kinase insert domain receptor
29
29
Number of compounds
29
fibroblast growth factor receptor 1
28
28
Number of compounds
28
platelet derived growth factor receptor beta
26
26
Number of compounds
26
platelet derived growth factor receptor alpha
25
25
Number of compounds
25
colony stimulating factor 1 receptor
22
22
Number of compounds
22
neurotrophic receptor tyrosine kinase 1
19
19
Number of compounds
19
fibroblast growth factor receptor 2
18
18
Number of compounds
18
fms related receptor tyrosine kinase 1
18
18
Number of compounds
18
MET proto-oncogene, receptor tyrosine kinase
18
18
Number of compounds
18
neurotrophic receptor tyrosine kinase 3
17
17
Number of compounds
17
neurotrophic receptor tyrosine kinase 2
16
16
Number of compounds
16
ALK receptor tyrosine kinase
16
16
Number of compounds
16
erb-b2 receptor tyrosine kinase 2
16
16
Number of compounds
16
Insulin receptor
15
15
Number of compounds
15
Insulin-like growth factor I receptor
15
15
Number of compounds
15
fibroblast growth factor receptor 3
15
15
Number of compounds
15
fms related receptor tyrosine kinase 4
15
15
Number of compounds
15
EPH receptor A2
14
14
Number of compounds
14
erb-b2 receptor tyrosine kinase 4
13
13
Number of compounds
13
fibroblast growth factor receptor 4
12
12
Number of compounds
12
EPH receptor A7
10
10
Number of compounds
10
EPH receptor B4
10
10
Number of compounds
10
macrophage stimulating 1 receptor
9
9
Number of compounds
9
EPH receptor A3
9
9
Number of compounds
9
EPH receptor B1
9
9
Number of compounds
9
EPH receptor A8
9
9
Number of compounds
9
activin A receptor type 1
9
9
Number of compounds
9
EPH receptor A1
8
8
Number of compounds
8
EPH receptor A5
7
7
Number of compounds
7
EPH receptor B2
7
7
Number of compounds
7
EPH receptor A6
7
7
Number of compounds
7
transforming growth factor beta receptor 1
7
7
Number of compounds
7
EPH receptor B6
6
6
Number of compounds
6
CXCR4
6
6
Number of compounds
6
CXCR1
6
6
Number of compounds
6
bone morphogenetic protein receptor type IB
5
5
Number of compounds
5
transforming growth factor beta receptor 2
5
5
Number of compounds
5
EPH receptor B3
5
5
Number of compounds
5
activin A receptor type 1B
5
5
Number of compounds
5
activin A receptor type IL
4
4
Number of compounds
4
erb-b2 receptor tyrosine kinase 3
4
4
Number of compounds
4
CCR5
3
3
Number of compounds
3
bone morphogenetic protein receptor type 2
2
2
Number of compounds
2
S1P2 receptor
2
2
Number of compounds
2
S1P1 receptor
2
2
Number of compounds
2
S1P3 receptor
2
2
Number of compounds
2
S1P4 receptor
2
2
Number of compounds
2
S1P5 receptor
2
2
Number of compounds
2
CCR2
2
2
Number of compounds
2
receptor activator of NF-kappa B
2
2
Number of compounds
2
CCR1
2
2
Number of compounds
2
anti-Mullerian hormone receptor type 2
1
1
Number of compounds
1
Interleukin-2 receptor
1
1
Number of compounds
1
Thrombopoietin receptor
1
1
Number of compounds
1
bone morphogenetic protein receptor type IA
1
1
Number of compounds
1
death receptor 4
1
1
Number of compounds
1
death receptor 5
1
1
Number of compounds
1
activin A receptor type 2B
1
1
Number of compounds
1
CXCR2
1
1
Number of compounds
1
CCR3
1
1
Number of compounds
1
Transforming growth factor β receptor
1
1
Number of compounds
1
CCR4
1
1
Number of compounds
1
CCR7
1
1
Number of compounds
1
CXCR3
1
1
Number of compounds
1
ACKR3
1
1
Number of compounds
1
Interferon γ receptor 1
1
1
Number of compounds
1
Interleukin 21 receptor
1
1
Number of compounds
1
EBCL-0017