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Cancer, in its diverse forms, evades the body's regulatory mechanisms, resulting in tumor growth, metastasis, and the disruption of normal bodily functions. Understanding the interactions of small molecules with cancer cells can help to identify biomarkers for cancer diagnosis, prognosis, and treatment response. Various protein targets and biological pathways play a role in different types of cancer, offering a vast opportunity for the discovery and development of new cancer therapies.
Library of Anticancer compounds, compiled from the latest data within the KEGG database, offers a comprehensive collection of molecules that are intricately linked to specific targets within significant cancer-related pathways, providing valuable insights into their mechanisms and potential therapeutic uses. The database of targets encompasses various oncogenes, tumor suppressor genes, growth factors, and enzymes involved in cancer cell signaling, proliferation, and survival.
This library includes approved drugs and investigational compounds, offering a valuable resource for research and drug development. It supports the identification of drug candidates and the repurposing of compounds for novel cancer targets.
Related terms: cancer, epoxide hydrolase, A2A, A3 receptor, fatty acid amide hydrolase, acetylcholinesterase, butyrylcholinesterase, carboxylesterase, Janus kinase
3-Fluoro-4-methoxy-5-(2-morpholinothiazol-4-yl)phenol shows inhibitory activity against androgen receptor.
2-[N-(3-Chlorophenyl)benzenesulfonamido]acetic acid inhibits alcohol dehydrogenase (NADP+).
dCeMM4 is a glue degrader that induces cyclin K Ubiquitination and degradation.
Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase.
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NoteAll the compounds with solubility below 10 mM are shipped as 2 mM solutions.
Cytochrome P450 family
1184
1184
Number of compounds
1184
Non-specific serine/threonine protein kinase
830
830
Number of compounds
830
Non-specific protein-tyrosine kinase
736
736
Number of compounds
736
Receptor protein-tyrosine kinase
677
677
Number of compounds
677
Growth factors
484
484
Number of compounds
484
Nuclear receptors
382
382
Number of compounds
382
Transcription factors
327
327
Number of compounds
327
Ion channels
283
283
Number of compounds
283
CDK family
213
213
Number of compounds
213
G protein-coupled receptors
199
199
Number of compounds
199
Histone deacetylases
181
181
Number of compounds
181
Mitogen-activated protein kinase
143
143
Number of compounds
143
Prostaglandin-endoperoxide synthase
143
143
Number of compounds
143
Aldo-keto reductase family 1
120
120
Number of compounds
120
ABC-type xenobiotic transporter
99
99
Number of compounds
99
Tau-protein kinase
98
98
Number of compounds
98
Histone modification proteins
93
93
Number of compounds
93
Lipid-phosphate phosphatase
88
88
Number of compounds
88
IkappaB kinase
76
76
Number of compounds
76
cAMP-dependent protein kinase
73
73
Number of compounds
73
Serine peptidases
65
65
Number of compounds
65
Endocytosis
64
64
Number of compounds
64
Ubiquitin system
64
64
Number of compounds
64
Protein-tyrosine-phosphatase
60
60
Number of compounds
60
Protein kinase C
59
59
Number of compounds
59
Glycosaminoglycan binding proteins
58
58
Number of compounds
58
Nitric-oxide synthase
57
57
Number of compounds
57
11beta-hydroxysteroid dehydrogenase
55
55
Number of compounds
55
Sulfotransferases
54
54
Number of compounds
54
Rho GTPases
49
49
Number of compounds
49
Myeloperoxidase
48
48
Number of compounds
48
Carbonyl reductase (NADPH)
44
44
Number of compounds
44
Histone acetyltransferase
42
42
Number of compounds
42
CD molecules
41
41
Number of compounds
41
Ca2+/calmodulin-dependent protein kinase
40
40
Number of compounds
40
GPCR adaptor proteins
40
40
Number of compounds
40
Protein serine/threonine phosphatases
40
40
Number of compounds
40
Bcl-2 family
38
38
Number of compounds
38
Gelatinase B
38
38
Number of compounds
38
Interstitial collagenase
36
36
Number of compounds
36
GTPase
35
35
Number of compounds
35
GTP-binding proteins
34
34
Number of compounds
34
Glutathione transferase
33
33
Number of compounds
33
Adenylate cyclase
32
32
Number of compounds
32
Cyclins
31
31
Number of compounds
31
Cytochromes
31
31
Number of compounds
31
Leukocyte elastase
31
31
Number of compounds
31
Glucuronosyltransferase
29
29
Number of compounds
29
Receptor protein serine/threonine kinase
29
29
Number of compounds
29
Transporters
29
29
Number of compounds
29
Beta-catenin
28
28
Number of compounds
28
Succinate dehydrogenase
27
27
Number of compounds
27
Mitogen-activated protein kinase kinase
24
24
Number of compounds
24
Type II transmembrane serine protease
24
24
Number of compounds
24
Phosphatidylinositol-4,5-bisphosphate 3-kinase
23
23
Number of compounds
23
Gelatinase A
21
21
Number of compounds
21
Pyruvate kinase
21
21
Number of compounds
21
Chaperones and folding catalysts
20
20
Number of compounds
20
Cathepsin L
19
19
Number of compounds
19
RNA polymerase II system
18
18
Number of compounds
18
Complex I
17
17
Number of compounds
17
ATPases
17
17
Number of compounds
17
Thioredoxin-disulfide reductase
17
17
Number of compounds
17
Adapter molecule
12
12
Number of compounds
12
DNA repair and recombination proteins
12
12
Number of compounds
12
Interleukins
12
12
Number of compounds
12
u-plasminogen activator
12
12
Number of compounds
12
Centrosome formation proteins
11
11
Number of compounds
11
Cytokines
11
11
Number of compounds
11
RNA-directed DNA polymerase
11
11
Number of compounds
11
ATP synthase-coupling factor 6, mitochondrial
10
10
Number of compounds
10
Heme oxygenase
10
10
Number of compounds
10
Hexokinase
10
10
Number of compounds
10
Peroxidase
10
10
Number of compounds
10
Phospholipase A2
10
10
Number of compounds
10
Stromelysin 1
10
10
Number of compounds
10
mRNA degradation factors
9
9
Number of compounds
9
1-phosphatidylinositol-4-phosphate 5-kinase
8
8
Number of compounds
8
Arylamine N-acetyltransferases
8
8
Number of compounds
8
Endothelin
8
8
Number of compounds
8
Hypoxia-inducible factor-proline dioxygenase
8
8
Number of compounds
8
Rho GTPase associated proteins
8
8
Number of compounds
8
Glucose-6-phosphate dehydrogenase
7
7
Number of compounds
7
Notch proteins
7
7
Number of compounds
7
Transmembrane protease serine 2
7
7
Number of compounds
7
Catalase
6
6
Number of compounds
6
Cysteine peptidases
6
6
Number of compounds
6
Histones
6
6
Number of compounds
6
NOD-like receptors
6
6
Number of compounds
6
Protein-serine/threonine phosphatase
6
6
Number of compounds
6
Actin-binding protein
5
5
Number of compounds
5
Cyclin-dependent kinase inhibitor
4
4
Number of compounds
4
Hepsin
4
4
Number of compounds
4
Isocitrate dehydrogenase
4
4
Number of compounds
4
Nuclear pore complex
4
4
Number of compounds
4
RNA helicase
4
4
Number of compounds
4
mTORC1 complex
4
4
Number of compounds
4
Actin-binding proteins
3
3
Number of compounds
3
NAD(P)H dehydrogenase
3
3
Number of compounds
3
NADPH oxidases
3
3
Number of compounds
3
Phospholipase D
3
3
Number of compounds
3
Prostaglandin-E synthase
3
3
Number of compounds
3
Peptidylprolyl isomerase
2
2
Number of compounds
2
6-phosphofructokinase
2
2
Number of compounds
2
Cell adhesion molecules
2
2
Number of compounds
2
Cytoskeleton proteins
2
2
Number of compounds
2
Isomerases
2
2
Number of compounds
2
Mitogen-activated protein kinase kinase kinase
2
2
Number of compounds
2
Myeloid leukemia factor
2
2
Number of compounds
2
RISC (RNA-induced silencing complex)
2
2
Number of compounds
2
Ribosomal proteins
2
2
Number of compounds
2
Superoxide dismutases
2
2
Number of compounds
2
Phosphoinositide phospholipase C
2
2
Number of compounds
2
4-methylthio 2-oxobutanoate reductase
1
1
Number of compounds
1
Adapter proteins
1
1
Number of compounds
1
Apoptotic regulators
1
1
Number of compounds
1
Choline kinase
1
1
Number of compounds
1
Diacylglycerol kinase
1
1
Number of compounds
1
Glutaminase
1
1
Number of compounds
1
Integrins
1
1
Number of compounds
1
Proteasome
1
1
Number of compounds
1
S-malonyltransferase
1
1
Number of compounds
1
Serine/threonine kinases
1
1
Number of compounds
1
Transport factors
1
1
Number of compounds
1
Y-family DNA polymerases
1
1
Number of compounds
1
EBCL-0037